HitPredict

Interactor 1: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	37005481, 17110958
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~WW, WW~WW
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 504 Hs			1 903
+	Hs
		125652 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		1294834 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		ITCH_HUMAN (1-903): 0: 926: 100.00
+	Hs
		125703 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		124986 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		1294856 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		1327908 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		WWP1_HUMAN (1-903): 0: 832: 57.54
+	Hs
		125235 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		1299600 NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		808226 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		808235 NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		808278 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		808041 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Mm
		93257 E9PXB7_MOUSE (8-504): 1.1e-114: 359: 19.11		E9PXB7_MOUSE (86-900): 0: 654: 34.22
+	Mm
		808342 NEDD4_MOUSE (28-504): 2.4e-113: 357: 16.98		NEDD4_MOUSE (13-426): 2.27e-52: 199: 18.38
+	Hs
		1336083 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Hs
		1334870 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		SMUF2_HUMAN (1-358): 2.56e-46: 180: 16.94
+	Hs
		808720 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		HECW1_HUMAN (26-479): 2.25e-13: 76.9: 10.76