HitPredict

Interactor 1: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Interactor 2: M3K3 (Q99759)
Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)
Gene: MAP3K3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	33571521
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 504 Hs			1 626
+	Hs
		1299609 NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73		M3K3_HUMAN (1-626): 0: 606: 100.00
+	Hs
		1306382 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		M3K3_HUMAN (1-626): 0: 606: 100.00
+	Hs
		808243 NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26		M3K3_HUMAN (1-626): 0: 606: 100.00
+	Hs
		1294887 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33
+	Mm
		103632 SMUF1_MOUSE (89-504): 7.42e-115: 357: 20.42		G5E8L8_MOUSE (1-622): 3.79e-178: 520: 64.49
+	Hs
		1299665 NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73		M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33
+	Hs
		1336125 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33
+	Hs
		809043 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33
+	Hs
		808330 NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26		M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33
+	Hs
		1306378 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		M3K3_HUMAN (1-626): 0: 606: 100.00
+	Hs
		681988 NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73		AKT1_HUMAN (247-622): 1.65e-126: 383: 21.67
+	Hs
		1299664 NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73		AKT3_HUMAN (291-622): 1.39e-124: 378: 23.08
+	Hs
		808570 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		PAK2_HUMAN (123-624): 8.76e-126: 383: 23.91
+	Hs
		681731 NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26		AKT1_HUMAN (247-622): 1.65e-126: 383: 21.67
+	Hs
		808324 NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26		AKT3_HUMAN (291-622): 1.39e-124: 378: 23.08
+	Hs
		1326796 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33
+	At
		1105338 UPL2_ARATH (216-504): 2.03e-50: 187: 10.47		KIN10_ARATH (361-623): 3.5e-131: 396: 31.70
+	Hs
		166601 MAGI1_HUMAN (69-305): 1.87e-39: 155: 18.32		DCLK1_HUMAN (21-624): 5.2e-136: 416: 16.90