HitPredict

Interactor 1: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Interactor 2: NSD3 (Q9BZ95)
Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)
Gene: NSD3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	38280479
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 504 Hs			1 1437
+	Hs
		808414 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		MSH6_HUMAN (233-594): 7.56e-72: 266: 18.55
+	Hs
		125489 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		808896 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		SETD2_HUMAN (1004-1320): 1.62e-59: 228: 32.18
+	Hs
		1080322 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		808137 NEDD4_HUMAN (40-504): 2.15e-103: 338: 19.26		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		1080361 SMUF2_HUMAN (99-504): 4.95e-107: 337: 19.19		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		808533 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		KMT2A_HUMAN (1131-1285): 7.1e-40: 164: 30.13
+	Hs
		808857 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		NSD1_HUMAN (91-724): 2.53e-28: 126: 15.30
+	Hs
		855546 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		MSH6_HUMAN (233-594): 7.56e-72: 266: 18.55
+	Zm
		9190 A0A1D6NNG0_MAIZE (3-304): 1.14e-34: 141: 18.48		A0A1D6EV07_MAIZE (329-1285): 2.2e-87: 317: 12.29
+	Hs
		808779 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		KMT2C_HUMAN (1278-1411): 2.31e-13: 77.9: 15.75
+	Hs
		1317577 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		SETD2_HUMAN (1004-1320): 1.62e-59: 228: 32.18
+	Hs
		809021 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		KMT2B_HUMAN (1323-1421): 9.58e-09: 62.5: 19.83
+	Hs
		855567 WWOX_HUMAN (166-263): 7.4e-29: 120: 30.61		MSH6_HUMAN (233-594): 7.56e-72: 266: 18.55
+	Hs
		975321 WWTR1_HUMAN (51-504): 2.59e-59: 202: 39.83		KMT2A_HUMAN (1131-1285): 7.1e-40: 164: 30.13
+	Hs
		1080470 WWC3_HUMAN (170-318): 1.24e-30: 128: 26.17		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Dm
		1115136 YAP1_DROME (52-268): 1.16e-44: 163: 29.25		TRR_DROME (1149-1284): 1e-17: 92: 36.50
+	Hs
		975337 HECW2_HUMAN (13-303): 1.56e-14: 79: 14.79		KMT2A_HUMAN (1131-1285): 7.1e-40: 164: 30.13