HitPredict

Interactor 1: YAP1 (P46937)
Transcriptional coactivator YAP1 (Yes-associated protein 1) (Protein yorkie homolog) (Yes-associated protein YAP65 homolog)
Gene: YAP1

Interactor 2: AMOL2 (Q9Y2J4)
Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP)
Gene: AMOTL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.756

Property	Details
Experiments	26598551, 21832154, 24366813, 25796446, 27684187, 30472188, 26933062, 38280479, 38223760, 24255178, 25751139, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0035329 - hippo signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 504 Hs			1 779
+	Hs
		125503 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		AMOT_HUMAN (1-740): 2.7e-70: 252: 32.32
+	Hs
		125805 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		AMOL2_HUMAN (1-779): 1.36e-71: 251: 100.00
+	Hs
		1119026 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		AMOT_HUMAN (1-740): 2.7e-70: 252: 32.32
+	Hs
		1119034 NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73		AMOT_HUMAN (1-740): 2.7e-70: 252: 32.32
+	Hs
		1119052 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		AMOT_HUMAN (1-740): 2.7e-70: 252: 32.32
+	Hs
		1327936 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		AMOL2_HUMAN (1-779): 1.36e-71: 251: 100.00
+	Hs
		808669 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		AMOT_HUMAN (1-740): 2.7e-70: 252: 32.32
+	Hs
		125569 WWP2_HUMAN (12-504): 8.56e-129: 397: 16.54		AMOL1_HUMAN (1-766): 4.56e-42: 167: 40.22
+	Hs
		1222263 NED4L_HUMAN (4-504): 4.82e-115: 364: 19.73		AMOL1_HUMAN (1-766): 4.56e-42: 167: 40.22
+	Hs
		1078893 ITCH_HUMAN (3-504): 3.59e-121: 378: 15.17		ITSN1_HUMAN (136-766): 1.5e-36: 150: 11.46
+	Hs
		1222267 WWP1_HUMAN (4-504): 1.27e-114: 361: 14.42		AMOL1_HUMAN (1-766): 4.56e-42: 167: 40.22
+	Hs
		808761 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		AMOL1_HUMAN (1-766): 4.56e-42: 167: 40.22
+	Mm
		809078 YAP1_MOUSE (35-504): 1.41e-115: 351: 91.70		AMOT_MOUSE (1-661): 2.13e-38: 156: 38.02
+	Hs
		724701 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		MYH9_HUMAN (16-773): 4.81e-28: 123: 9.57
+	Hs
		728454 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		MYH11_HUMAN (207-773): 7.92e-24: 110: 11.36
+	Hs
		725106 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		MYH10_HUMAN (222-773): 1.7e-23: 109: 10.95
+	Hs
		551845 SMUF1_HUMAN (89-504): 7.79e-117: 363: 20.05		DESP_HUMAN (16-454): 7.49e-11: 68.1: 12.02
+	Hs
		551633 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		DESP_HUMAN (16-454): 7.49e-11: 68.1: 12.02
+	Hs
		808981 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		EP15R_HUMAN (483-673): 1.1e-10: 67.4: 13.09
+	Hs
		808624 YAP1_HUMAN (1-504): 7.71e-118: 357: 100.00		PLEC_HUMAN (191-769): 1.21e-09: 64.3: 9.88