HitPredict

Interactor 1: IQGA1 (P46940)
Ras GTPase-activating-like protein IQGAP1 (p195)
Gene: IQGAP1

Interactor 2: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	31871319, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ras~RasGAP
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019901 - protein kinase binding GO:0030426 - growth cone GO:0043005 - neuron projection and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1657 Hs			1 192
+	Hs
		809255 IQGA1_HUMAN (1-1657): 0: 1732: 100.00		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		545255 IQGA1_HUMAN (1-1657): 0: 1732: 100.00		RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54
+	Hs
		809436 IQGA1_HUMAN (1-1657): 0: 1732: 100.00		RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32
+	Hs
		809264 IQGA1_HUMAN (1-1657): 0: 1732: 100.00		RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79
+	Hs
		809234 IQGA1_HUMAN (1-1657): 0: 1732: 100.00		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		809241 IQGA1_HUMAN (1-1657): 0: 1732: 100.00		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		436197 IQGA1_HUMAN (1-1657): 0: 1732: 100.00		RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79
+	Hs
		564448 IQGA1_HUMAN (1-1657): 0: 1732: 100.00		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49
+	Mm
		925821 IQGA1_MOUSE (1-1657): 0: 1688: 95.96		RAC1_MOUSE (1-192): 1.92e-84: 249: 92.71
+	Mm
		892736 IQGA1_MOUSE (1-1657): 0: 1688: 95.96		CDC42_MOUSE (1-192): 3.66e-77: 230: 68.75
+	Hs
		925404 IQGA3_HUMAN (13-1657): 0: 1561: 58.87		RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71
+	Hs
		1201453 IQGA3_HUMAN (13-1657): 0: 1561: 58.87		RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32
+	Hs
		892462 IQGA3_HUMAN (13-1657): 0: 1561: 58.87		RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00
+	Hs
		894176 IQGA3_HUMAN (13-1657): 0: 1561: 58.87		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		900647 IQGA3_HUMAN (13-1657): 0: 1561: 58.87		RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32
+	Hs
		436384 IQGA3_HUMAN (13-1657): 0: 1561: 58.87		RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79
+	Hs
		564593 IQGA3_HUMAN (13-1657): 0: 1561: 58.87		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49
+	Hs
		892356 IQGA2_HUMAN (254-1657): 0: 1321: 54.09		RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00
+	Hs
		893981 IQGA2_HUMAN (254-1657): 0: 1321: 54.09		CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75
+	Hs
		564517 IQGA2_HUMAN (254-1657): 0: 1321: 54.09		RHOQ_HUMAN (4-189): 1.4e-73: 222: 63.49