HitPredict

Interactor 1: SMC3 (P47037)
Structural maintenance of chromosomes protein 3 (DA-box protein SMC3)
Gene: SMC3

Interactor 2: PDS5 (Q04264)
Sister chromatid cohesion protein PDS5 (Precocious dissociation of sisters protein 5)
Gene: PDS5

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.699

Property	Details
Experiments	19268589, 34259632, 21441928, 22912589, 21139566
Identification Methods	affinity chromatography technology, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0007064 - mitotic sister chromatid cohesion GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1230 Sc			1 1277
+	Hs
		1345702 SMC3_HUMAN (1-1228): 4.16e-91: 322: 30.20		PDS5B_HUMAN (3-1272): 0: 1244: 18.31
+	Hs
		1100586 SMC3_HUMAN (1-1228): 4.16e-91: 322: 30.20		PDS5A_HUMAN (4-1252): 0: 1216: 18.06
+	Xl
		292740 SMC3_XENLA (1-1228): 4.69e-90: 318: 30.15		PD5BB_XENLA (2-1271): 0: 1215: 18.38
+	Mm
		93885 SMC3_MOUSE (1-1228): 2.61e-91: 322: 30.28		E9QPI5_MOUSE (4-1265): 0: 1209: 17.95
+	Xl
		1115499 Q8AW91_XENLA (1-1228): 2.76e-91: 322: 30.12		PD5BA_XENLA (2-1271): 0: 1203: 18.31
+	Xl
		1117310 Q8AW91_XENLA (1-1228): 2.76e-91: 322: 30.12		PD5AB_XENLA (5-1251): 0: 1202: 17.07
+	Sc
		700799 SMC1_YEAST (2-1215): 4.84e-68: 253: 16.53		PDS5_YEAST (1-1277): 0: 1271: 100.00
+	Xl
		292738 SMC3_XENLA (1-1228): 4.69e-90: 318: 30.15		PD5BA_XENLA (2-1271): 0: 1203: 18.31
+	Xl
		292739 SMC3_XENLA (1-1228): 4.69e-90: 318: 30.15		PD5AA_XENLA (3-1251): 0: 1200: 17.11
+	Mm
		1118817 SMC1A_MOUSE (2-1222): 6.7e-73: 268: 16.41		PDS5B_MOUSE (3-1272): 0: 1249: 18.49
+	Hs
		1057405 SMC1A_HUMAN (2-1222): 6.7e-73: 268: 16.41		PDS5B_HUMAN (3-1272): 0: 1244: 18.31
+	Hs
		1057273 SMC1A_HUMAN (2-1222): 6.7e-73: 268: 16.41		PDS5A_HUMAN (4-1252): 0: 1216: 18.06
+	Mm
		93884 SMC1A_MOUSE (2-1222): 6.7e-73: 268: 16.41		E9QPI5_MOUSE (4-1265): 0: 1209: 17.95
+	Mm
		1149127 SMC1A_MOUSE (2-1222): 6.7e-73: 268: 16.41		PDS5A_MOUSE (4-1265): 0: 1192: 17.95
+	Xl
		292728 SMC1A_XENLA (2-1222): 2.68e-67: 250: 16.09		PD5BA_XENLA (2-1271): 0: 1203: 18.31
+	Xl
		292729 SMC1A_XENLA (2-1222): 2.68e-67: 250: 16.09		PD5AB_XENLA (5-1251): 0: 1202: 17.07
+	Xl
		292730 SMC1A_XENLA (2-1222): 2.68e-67: 250: 16.09		PD5AA_XENLA (3-1251): 0: 1200: 17.11
+	Sp
		193880 SMC3_SCHPO (1-1223): 1.52e-78: 284: 33.20		PDS5_SCHPO (8-1196): 0: 978: 23.44
+	Sp
		293288 SMC1_SCHPO (2-1215): 9.46e-66: 246: 16.94		PDS5_SCHPO (8-1196): 0: 978: 23.44
+	Hs
		69118 SMC1A_HUMAN (2-1222): 6.7e-73: 268: 16.41		A9IYQ1_HUMAN (1077-1272): 5.56e-45: 166: 16.59