HitPredict

Interactor 1: SMC3 (P47037)
Structural maintenance of chromosomes protein 3 (DA-box protein SMC3)
Gene: SMC3

Interactor 2: SMC4 (Q12267)
Structural maintenance of chromosomes protein 4
Gene: SMC4

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.775

Property	Details
Experiments	11087867, 21441928
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	SMC_hinge~SMC_hinge, SMC_N~SMC_N
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0016887 - ATP hydrolysis activity GO:0051301 - cell division
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1230 Sc			1 1418
+	Sc
		758746 SMC3_YEAST (1-1230): 4.94e-108: 370: 100.00		SMC2_YEAST (154-1409): 1.02e-101: 354: 17.17
+	Ce
		999500 SMC4_CAEEL (1-1214): 2.96e-76: 280: 16.11		MIX1_CAEEL (154-1415): 4.85e-110: 379: 18.90
+	Hs
		311633 SMC2_HUMAN (1-1229): 1.89e-77: 281: 19.00		SMC4_HUMAN (79-1417): 2.8e-108: 375: 33.83
+	Sp
		780419 SMC2_SCHPO (1-1209): 1.52e-80: 290: 18.51		SMC4_SCHPO (152-1416): 3.84e-102: 358: 38.97
+	Sc
		810757 SMC3_YEAST (1-1230): 4.94e-108: 370: 100.00		SMC3_YEAST (154-1410): 5.19e-67: 250: 15.71
+	Hs
		1057429 SMC3_HUMAN (1-1228): 4.16e-91: 322: 30.20		SMC1A_HUMAN (154-1415): 4.93e-81: 294: 19.95
+	Mm
		1321813 SMC3_MOUSE (1-1228): 2.61e-91: 322: 30.28		SMC1A_MOUSE (154-1415): 3.78e-81: 294: 19.87
+	Bt
		333283 SMC3_BOVIN (1-1228): 2.61e-91: 322: 29.94		SMC1A_BOVIN (154-1415): 4.88e-81: 294: 19.87
+	Sc
		700779 SMC3_YEAST (1-1230): 4.94e-108: 370: 100.00		SMC1_YEAST (154-1409): 1.81e-63: 239: 20.43
+	Ce
		823188 MIX1_CAEEL (1-1213): 1.42e-75: 276: 17.21		DPY27_CAEEL (139-1417): 3.58e-93: 333: 24.32
+	Hs
		1242602 SMC3_HUMAN (1-1228): 4.16e-91: 322: 30.20		SMC1B_HUMAN (155-1415): 7.08e-78: 284: 18.55
+	Xl
		292733 Q8AW91_XENLA (1-1228): 2.76e-91: 322: 30.12		SMC1A_XENLA (154-1415): 2.49e-75: 277: 19.32
+	Xl
		292725 SMC3_XENLA (1-1228): 4.69e-90: 318: 30.15		SMC1A_XENLA (154-1415): 2.49e-75: 277: 19.32
+	Mm
		1265313 SMC3_MOUSE (1-1228): 2.61e-91: 322: 30.28		SMC1B_MOUSE (154-1415): 2.53e-73: 270: 18.45
+	Hs
		1357882 SMC3_HUMAN (1-1228): 4.16e-91: 322: 30.20		SMC3_HUMAN (154-1409): 2.34e-67: 251: 17.34
+	Xl
		292736 SMC3_XENLA (1-1228): 4.69e-90: 318: 30.15		SMC3_XENLA (154-1409): 2.98e-66: 248: 16.69
+	Hs
		311648 SMC3_HUMAN (1-1228): 4.16e-91: 322: 30.20		SMC2_HUMAN (154-1408): 1.36e-64: 243: 15.82
+	Sp
		193869 SMC3_SCHPO (1-1223): 1.52e-78: 284: 33.20		SMC3_SCHPO (154-1409): 6.47e-76: 278: 16.71
+	Sp
		193871 SMC3_SCHPO (1-1223): 1.52e-78: 284: 33.20		SMC1_SCHPO (154-1409): 6.26e-68: 253: 18.88