HitPredict

Interactor 1: SNX4 (P47057)
Sorting nexin-4 (Autophagy-related protein 24) (Cytoplasm to vacuole targeting protein 13)
Gene: SNX4

Interactor 2: SNX41 (Q04053)
Sorting nexin-41
Gene: SNX41

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.973

Property	Details
Experiments	11283351, 12554655, 16429126, 15263065, 16554755, 19591838, 37968396, 20826334, 22875988
Identification Methods	two hybrid pooling approach, affinity chromatography technology, two hybrid, two hybrid array, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PX~PX
Common GO terms	GO:0005829 - cytosol GO:0006886 - intracellular protein transport GO:0010009 - cytoplasmic side of endosome membrane GO:0032266 - phosphatidylinositol-3-phosphate binding GO:0042147 - retrograde transport, endosome to Golgi
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 423 Sc			1 625
+	Sc
		811081 SNX4_YEAST (1-423): 1.85e-95: 294: 100.00		ATG20_YEAST (20-597): 1.1e-75: 255: 24.47
+	At
		1226088 SNX2A_ARATH (27-422): 1.44e-73: 242: 17.49		SNX2A_ARATH (1-554): 3.13e-80: 266: 13.37
+	At
		82560 SNX2A_ARATH (27-422): 1.44e-73: 242: 17.49		SNX2B_ARATH (8-554): 3.58e-75: 252: 14.00
+	At
		82561 SNX1_ARATH (6-423): 7.91e-75: 240: 21.07		SNX2B_ARATH (8-554): 3.58e-75: 252: 14.00
+	At
		82559 SNX2B_ARATH (27-422): 9.79e-72: 237: 17.30		SNX2B_ARATH (8-554): 3.58e-75: 252: 14.00
+	Hs
		240317 SNX2_HUMAN (9-422): 1.53e-79: 256: 18.16		SNX2_HUMAN (37-554): 1.21e-66: 228: 10.58
+	Hs
		240386 SNX2_HUMAN (9-422): 1.53e-79: 256: 18.16		SNX1_HUMAN (3-554): 7.47e-66: 226: 11.05
+	Hs
		1040456 SNX1_HUMAN (4-422): 6.66e-79: 254: 16.28		SNX1_HUMAN (3-554): 7.47e-66: 226: 11.05
+	Sc
		811057 SNX4_YEAST (1-423): 1.85e-95: 294: 100.00		SNX4_YEAST (100-552): 5.6e-50: 181: 14.88
+	Sc
		701305 SNX4_YEAST (1-423): 1.85e-95: 294: 100.00		VPS17_YEAST (1-467): 2.02e-47: 176: 13.73
+	Hs
		240322 SNX2_HUMAN (9-422): 1.53e-79: 256: 18.16		SNX4_HUMAN (43-464): 2e-59: 207: 16.70
+	At
		1226089 SNX2A_ARATH (27-422): 1.44e-73: 242: 17.49		SNX1_ARATH (107-554): 1.74e-53: 189: 11.37
+	At
		1322825 SNX1_ARATH (6-423): 7.91e-75: 240: 21.07		SNX1_ARATH (107-554): 1.74e-53: 189: 11.37
+	Hs
		240464 SNX2_HUMAN (9-422): 1.53e-79: 256: 18.16		SNX5_HUMAN (113-502): 4.52e-47: 172: 9.52
+	Hs
		1040543 SNX1_HUMAN (4-422): 6.66e-79: 254: 16.28		SNX5_HUMAN (113-502): 4.52e-47: 172: 9.52
+	Hs
		240410 SNX2_HUMAN (9-422): 1.53e-79: 256: 18.16		SNX32_HUMAN (112-502): 2.91e-46: 170: 9.50
+	Hs
		1040476 SNX1_HUMAN (4-422): 6.66e-79: 254: 16.28		SNX32_HUMAN (112-502): 2.91e-46: 170: 9.50
+	Dm
		1370164 Q9VQQ6_DROME (2-421): 9e-75: 242: 18.86		Q9VLQ9_DROME (38-480): 6.78e-47: 173: 10.46