HitPredict

Interactor 1: LSM8 (P47093)
U6 snRNA-associated Sm-like protein LSm8
Gene: LSM8

Interactor 2: PRP24 (P49960)
U4/U6 snRNA-associated-splicing factor PRP24 (U4/U6 snRNP protein)
Gene: PRP24

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.967

Property	Details
Experiments	10747033, 10900456, 23560879, 11720284, 16554755, 25805862, 18971323, 16429126
Identification Methods	biochemical, two hybrid, affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	LSM~Lsm_interact, LSM~RRM_occluded
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005681 - spliceosomal complex GO:0005688 - U6 snRNP
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 109 Sc			1 444
+	Sc
		837113 LSM7_YEAST (5-71): 3.29e-13: 62.3: 15.00		PRP24_YEAST (1-444): 2.66e-80: 256: 100.00
+	Sc
		376838 LSM8_YEAST (1-109): 1.64e-35: 118: 100.00		PABP_YEAST (2-323): 3.4e-55: 194: 15.39
+	Sc
		837114 LSM3_YEAST (5-76): 5.4e-10: 53.5: 22.22		PRP24_YEAST (1-444): 2.66e-80: 256: 100.00
+	Sc
		376834 LSM1_YEAST (2-108): 1.12e-29: 106: 20.18		PABP_YEAST (2-323): 3.4e-55: 194: 15.39
+	Sc
		376893 LSM3_YEAST (5-76): 5.4e-10: 53.5: 22.22		PABP_YEAST (2-323): 3.4e-55: 194: 15.39
+	Hs
		912047 RUXG_HUMAN (3-69): 6.78e-25: 90.8: 20.29		SF3B4_HUMAN (22-190): 1.88e-23: 103: 16.58
+	Hs
		68422 RUXGL_HUMAN (3-69): 6.48e-23: 85.8: 20.29		SF3B4_HUMAN (22-190): 1.88e-23: 103: 16.58
+	Hs
		927957 RSMN_HUMAN (2-64): 5.94e-17: 74.7: 20.00		SF3B4_HUMAN (22-190): 1.88e-23: 103: 16.58
+	Hs
		538970 RSMB_HUMAN (2-64): 9.82e-17: 74.3: 20.00		SF3B4_HUMAN (22-190): 1.88e-23: 103: 16.58
+	Mm
		646096 RSMB_MOUSE (2-64): 9.96e-17: 73.9: 20.00		TIA1_MOUSE (3-119): 5.5e-11: 65.9: 11.19