Interactor 1: VPS25 (P47142)
Vacuolar protein-sorting-associated protein 25 (ESCRT-II complex subunit VPS25)
Gene: VPS25

Interactor 2: SNF8 (Q12483)
Vacuolar-sorting protein SNF8 (ESCRT-II complex subunit VPS22) (Vacuolar protein-sorting-associated protein 22)
Gene: SNF8

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.92 1.00 0.962

The method score is based on:

Property Details
Experiments 11283351, 20305637, 15086794, 15469844, 18719252, 16554755, 37968396
Identification Methods two hybrid pooling approach, pull down, two hybrid, x-ray crystallography, affinity chromatography technology, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains EAP30~ESCRT-II
Common GO terms GO:0000433 - carbon catabolite repression of transcription from RNA polymerase II promoter by glucose
GO:0000814 - ESCRT II complex
GO:0006623 - protein targeting to vacuole
GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0043328 - protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
and 1 others

more...

Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 202
Sc

1 233
+ Hs
+ At
+ Dm

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Last updated: 15 Jul 2024