HitPredict

Interactor 1: JHD2 (P47156)
Histone demethylase JHD2 (EC 1.14.11.67) (Jumonji/ARID domain-containing protein 2) ([histone H3]-trimethyl-L-lysine(4) demethylase JHD2)
Gene: JHD2

Interactor 2: H3 (P61830)
Histone H3
Gene: HHT1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.710

Property	Details
Experiments	17310254, 17875926, 32014433, 36167807, 23091032
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Sc			1 136
+	Hs
		1086304 KDM5D_HUMAN (2-722): 0: 606: 23.17		H31T_HUMAN (1-136): 1.96e-61: 186: 86.03
+	Hs
		782353 KDM5C_HUMAN (2-722): 0: 603: 22.28		H32_HUMAN (1-136): 6.6e-61: 185: 88.97
+	Hs
		935339 KDM5B_HUMAN (2-722): 0: 598: 24.24		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		666522 KDM5A_HUMAN (2-712): 0: 584: 23.61		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		666523 KDM5A_HUMAN (2-712): 0: 584: 23.61		H33_HUMAN (1-136): 1.25e-61: 187: 90.44
+	Hs
		666535 KDM5A_HUMAN (2-712): 0: 584: 23.61		H31T_HUMAN (1-136): 1.96e-61: 186: 86.03
+	Dm
		356114 KDM5_DROME (2-725): 0: 584: 24.46		H3_DROME (1-136): 6.6e-61: 185: 88.97
+	Hs
		666539 KDM5A_HUMAN (2-712): 0: 584: 23.61		H32_HUMAN (1-136): 6.6e-61: 185: 88.97
+	Sp
		457185 LID2_SCHPO (14-691): 1.16e-108: 363: 18.16		H31_SCHPO (1-136): 1.17e-59: 182: 92.65
+	Sp
		498409 LID2_SCHPO (14-691): 1.16e-108: 363: 18.16		H33_SCHPO (1-136): 1.86e-58: 179: 91.91
+	Hs
		301134 KDM4B_HUMAN (287-624): 1.07e-77: 272: 24.48		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Dm
		356095 KDM4A_DROME (298-706): 1.27e-83: 275: 20.62		H3_DROME (1-136): 6.6e-61: 185: 88.97
+	Hs
		301136 KDM4B_HUMAN (287-624): 1.07e-77: 272: 24.48		H33_HUMAN (1-136): 1.25e-61: 187: 90.44
+	Sc
		902025 ECM5_YEAST (4-608): 5.68e-79: 278: 16.11		H3_YEAST (1-136): 1.51e-56: 174: 100.00
+	Hs
		183098 KDM6A_HUMAN (277-690): 4.53e-74: 263: 14.83		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		301146 KDM4B_HUMAN (287-624): 1.07e-77: 272: 24.48		H3C_HUMAN (1-136): 8.2e-59: 179: 86.03
+	Hs
		183122 KDM6A_HUMAN (277-690): 4.53e-74: 263: 14.83		H31T_HUMAN (1-136): 1.96e-61: 186: 86.03
+	Hs
		183127 KDM6A_HUMAN (277-690): 4.53e-74: 263: 14.83		H32_HUMAN (1-136): 6.6e-61: 185: 88.97
+	Hs
		935232 KDM4C_HUMAN (290-610): 4.82e-73: 258: 23.99		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		952622 KDM4C_HUMAN (290-610): 4.82e-73: 258: 23.99		H33_HUMAN (1-136): 1.25e-61: 187: 90.44