HitPredict

Interactor 1: MSS4 (P47224)
Guanine nucleotide exchange factor MSS4 (Rab-interacting factor)
Gene: RABIF

Interactor 2: RAB8A (P61006)
Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel)
Gene: RAB8A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.900

Property	Details
Experiments	33961781, 16541104, 26824392, 29125462
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, fluorescent resonance energy transfer, anti bait coimmunoprecipitation, x-ray crystallography
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	Mss4~Ras
Common GO terms	GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 123 Hs			1 207
+	Hs
		812736 MSS4_HUMAN (1-123): 1.15e-71: 211: 100.00		RAB10_HUMAN (3-181): 4.07e-93: 272: 75.98
+	Hs
		812732 MSS4_HUMAN (1-123): 1.15e-71: 211: 100.00		RAB13_HUMAN (1-206): 3.19e-89: 262: 61.17
+	Hs
		812737 MSS4_HUMAN (1-123): 1.15e-71: 211: 100.00		RAB1A_HUMAN (1-204): 1.23e-87: 258: 54.41
+	Mm
		918998 MSS4_MOUSE (1-123): 1.15e-71: 211: 93.50		RAB1A_MOUSE (1-204): 1.23e-87: 258: 54.41
+	Hs
		812757 MSS4_HUMAN (1-123): 1.15e-71: 211: 100.00		RAB1B_HUMAN (1-204): 7.39e-87: 256: 51.96
+	Hs
		812751 MSS4_HUMAN (1-123): 1.15e-71: 211: 100.00		RAB8B_HUMAN (1-207): 6.41e-86: 253: 82.61
+	Dm
		183445 MSS4_DROME (13-123): 3.14e-52: 162: 39.29		O15971_DROME (3-204): 1.35e-92: 271: 68.81
+	Dm
		185729 MSS4_DROME (13-123): 3.14e-52: 162: 39.29		O18338_DROME (1-207): 1.83e-83: 247: 79.23
+	Dm
		185502 MSS4_DROME (13-123): 3.14e-52: 162: 39.29		O18332_DROME (2-203): 2.17e-82: 245: 50.99