HitPredict

Interactor 1: RP3A (P47708)
Rabphilin-3A (Exophilin-1)
Gene: Rph3a

Interactor 2: RAB8A (P55258)
Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel)
Gene: RAB8A

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	12578829, 11773082, 14722103
Identification Methods	affinity chromatography technology, coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FYVE_2~Ras
Common GO terms	GO:0008021 - synaptic vesicle GO:0031267 - small GTPase binding GO:0043005 - neuron projection GO:0043197 - dendritic spine GO:0045202 - synapse
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 681 Mm			1 207
+	Hs
		894828 RP3A_HUMAN (1-681): 0: 601: 85.71		RAB8A_HUMAN (1-207): 3.71e-89: 262: 97.10
+	Hs
		1273014 RP3A_HUMAN (1-681): 0: 601: 85.71		RAB8B_HUMAN (1-207): 8.82e-89: 261: 83.58
+	Hs
		894790 SYTL4_HUMAN (46-673): 3.64e-124: 385: 22.07		RAB8A_HUMAN (1-207): 3.71e-89: 262: 97.10
+	Hs
		1273004 SYTL4_HUMAN (46-673): 3.64e-124: 385: 22.07		RAB8B_HUMAN (1-207): 8.82e-89: 261: 83.58
+	Mm
		877205 SYTL4_MOUSE (46-673): 7.38e-120: 374: 21.90		RAB8A_MOUSE (1-207): 9.99e-90: 263: 100.00
+	Hs
		914274 SYTL4_HUMAN (46-673): 3.64e-124: 385: 22.07		RB11A_HUMAN (4-204): 2.83e-84: 250: 41.55
+	Hs
		914240 SYTL5_HUMAN (46-680): 5.19e-118: 371: 20.06		RB11A_HUMAN (4-204): 2.83e-84: 250: 41.55
+	Hs
		129082 SYT5_HUMAN (333-679): 5.87e-90: 287: 29.02		RAB1A_HUMAN (1-204): 8.1e-90: 264: 53.43
+	Hs
		1134943 SYT6_HUMAN (235-674): 6.13e-87: 283: 25.91		RAB1B_HUMAN (1-204): 5.3e-89: 261: 51.96
+	Mm
		877194 RPH3L_MOUSE (1-291): 2.35e-78: 254: 38.51		RAB8A_MOUSE (1-207): 9.99e-90: 263: 100.00
+	Hs
		895496 SYTL3_HUMAN (527-681): 3.52e-21: 100: 21.15		RAB10_HUMAN (3-181): 5.3e-93: 271: 75.98
+	Mm
		895586 RIMS1_MOUSE (61-660): 1.76e-15: 82.7: 11.97		RAB10_MOUSE (3-181): 5.3e-93: 271: 75.98