HitPredict

Interactor 1: PA24A (P47712)
Cytosolic phospholipase A2 (cPLA2) (Phospholipase A2 group IVA) [Includes: Phospholipase A2 (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase); Lysophospholipase (EC 3.1.1.5)]
Gene: PLA2G4A

Interactor 2: CASP7 (P55210)
Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
Gene: CASP7

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	9875225
Identification Methods	protease assay, enzymatic study
Interaction Type	cleavage reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 749 Hs			1 303
+	Hs
		788161 PA24A_HUMAN (1-749): 0: 911: 100.00		CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03
+	Hs
		812823 PA24A_HUMAN (1-749): 0: 911: 100.00		CASP8_HUMAN (9-301): 8.96e-93: 284: 34.42
+	Hs
		667436 PA24A_HUMAN (1-749): 0: 911: 100.00		CASP1_HUMAN (1-301): 8.45e-79: 246: 21.04
+	Hs
		473775 PA24B_HUMAN (10-139): 4.7e-23: 106: 26.72		CASP7_HUMAN (1-303): 2.97e-157: 442: 100.00
+	Hs
		473774 PA24B_HUMAN (10-139): 4.7e-23: 106: 26.72		CASP3_HUMAN (60-301): 1.88e-114: 333: 57.03
+	Hs
		473779 PA24B_HUMAN (10-139): 4.7e-23: 106: 26.72		CASP8_HUMAN (9-301): 8.96e-93: 284: 34.42
+	Hs
		473772 PA24B_HUMAN (10-139): 4.7e-23: 106: 26.72		CASP1_HUMAN (1-301): 8.45e-79: 246: 21.04