HitPredict

Interactor 1: CAZA2 (P47755)
F-actin-capping protein subunit alpha-2 (CapZ alpha-2)
Gene: CAPZA2

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	26186194, 26496610, 28514442, 33961781, 20697350
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0015629 - actin cytoskeleton GO:0051015 - actin filament binding GO:0065003 - protein-containing complex assembly GO:0070062 - extracellular exosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 286 Hs			1 639
+	Hs
		857263 CAZA1_HUMAN (1-286): 5.83e-156: 438: 86.71		CD2AP_HUMAN (1-639): 9.29e-139: 420: 100.00
+	Hs
		813121 CAZA2_HUMAN (1-286): 2.44e-159: 446: 100.00		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		857188 CAZA1_HUMAN (1-286): 5.83e-156: 438: 86.71		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		857099 CAZA1_HUMAN (1-286): 5.83e-156: 438: 86.71		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Hs
		298962 CAZA2_HUMAN (1-286): 2.44e-159: 446: 100.00		SRBS2_HUMAN (6-215): 1e-18: 92.7: 18.40