HitPredict

Interactor 1: ID4 (P47928)
DNA-binding protein inhibitor ID-4 (Class B basic helix-loop-helix protein 27) (bHLHb27) (Inhibitor of DNA binding 4) (Inhibitor of differentiation 4)
Gene: ID4

Interactor 2: OLIG2 (Q13516)
Oligodendrocyte transcription factor 2 (Oligo2) (Class B basic helix-loop-helix protein 1) (bHLHb1) (Class E basic helix-loop-helix protein 19) (bHLHe19) (Protein kinase C-binding protein 2) (Protein kinase C-binding protein RACK17)
Gene: OLIG2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15280210
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0045665 - negative regulation of neuron differentiation GO:0045944 - positive regulation of transcription by RNA polymerase II and 1 others more... GO:0046983 - protein dimerization activity
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 161 Hs			1 323
+	Mm
		781013 ID4_MOUSE (1-161): 3.39e-62: 190: 98.14		OLIG2_MOUSE (1-323): 2.28e-60: 197: 96.29
+	Mm
		781010 ID2_MOUSE (1-148): 1.17e-41: 137: 42.57		OLIG2_MOUSE (1-323): 2.28e-60: 197: 96.29
+	Hs
		970566 ID2_HUMAN (1-148): 2.51e-41: 136: 43.24		OLIG2_HUMAN (1-323): 1e-59: 196: 100.00
+	Hs
		616610 ID4_HUMAN (1-161): 1.67e-63: 194: 100.00		MYF6_HUMAN (49-249): 4.26e-28: 110: 16.67
+	Hs
		568188 ID4_HUMAN (1-161): 1.67e-63: 194: 100.00		TAL1_HUMAN (10-245): 7.94e-27: 109: 18.75
+	Hs
		814916 ID4_HUMAN (1-161): 1.67e-63: 194: 100.00		NGN3_HUMAN (25-243): 2.25e-27: 108: 20.09
+	Hs
		814909 ID4_HUMAN (1-161): 1.67e-63: 194: 100.00		FIGLA_HUMAN (46-268): 1.31e-26: 106: 17.86
+	Hs
		814911 ID4_HUMAN (1-161): 1.67e-63: 194: 100.00		OLIG1_HUMAN (96-226): 1.2e-21: 94.3: 43.57
+	Mm
		781014 ID4_MOUSE (1-161): 3.39e-62: 190: 98.14		OLIG1_MOUSE (49-258): 9.55e-20: 88.9: 31.63
+	Hs
		526742 ID1_HUMAN (12-161): 1.12e-51: 163: 37.42		MYF5_HUMAN (32-270): 2.83e-29: 114: 14.63
+	Mm
		589139 ID1_MOUSE (35-149): 7.26e-47: 152: 40.00		TAL1_MOUSE (10-245): 2.24e-27: 110: 17.23
+	Hs
		526743 ID2_HUMAN (1-148): 2.51e-41: 136: 43.24		MYF5_HUMAN (32-270): 2.83e-29: 114: 14.63
+	Hs
		970588 ID2_HUMAN (1-148): 2.51e-41: 136: 43.24		OLIG1_HUMAN (96-226): 1.2e-21: 94.3: 43.57
+	Hs
		526744 ID3_HUMAN (1-135): 2.13e-33: 116: 44.44		MYF5_HUMAN (32-270): 2.83e-29: 114: 14.63
+	Mm
		781011 ID2_MOUSE (1-148): 1.17e-41: 137: 42.57		OLIG1_MOUSE (49-258): 9.55e-20: 88.9: 31.63