HitPredict

Interactor 1: ID4 (P47928)
DNA-binding protein inhibitor ID-4 (Class B basic helix-loop-helix protein 27) (bHLHb27) (Inhibitor of DNA binding 4) (Inhibitor of differentiation 4)
Gene: ID4

Interactor 2: NGN3 (Q9Y4Z2)
Neurogenin-3 (NGN-3) (Class A basic helix-loop-helix protein 7) (bHLHa7) (Protein atonal homolog 5)
Gene: NEUROG3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046983 - protein dimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 161 Hs			1 214
+	Hs
		546072 ID4_HUMAN (1-161): 1.67e-63: 194: 100.00		MYOG_HUMAN (16-212): 1.13e-29: 111: 19.62
+	Hs
		551480 ID4_HUMAN (1-161): 1.67e-63: 194: 100.00		TFE2_HUMAN (1-186): 1.08e-26: 108: 18.52
+	Hs
		568188 ID4_HUMAN (1-161): 1.67e-63: 194: 100.00		TAL1_HUMAN (32-212): 1.41e-27: 108: 25.13
+	Hs
		524549 ID4_HUMAN (1-161): 1.67e-63: 194: 100.00		LYL1_HUMAN (3-208): 1.11e-25: 102: 22.60
+	Hs
		814906 ID4_HUMAN (1-161): 1.67e-63: 194: 100.00		OLIG2_HUMAN (28-165): 4.29e-20: 88: 26.28
+	Mm
		781013 ID4_MOUSE (1-161): 3.39e-62: 190: 98.14		OLIG2_MOUSE (28-163): 2.86e-21: 91.5: 27.39
+	Hs
		526742 ID1_HUMAN (12-161): 1.12e-51: 163: 37.42		MYF5_HUMAN (7-196): 5.16e-30: 113: 19.27
+	Hs
		546071 ID1_HUMAN (12-161): 1.12e-51: 163: 37.42		MYOG_HUMAN (16-212): 1.13e-29: 111: 19.62
+	Hs
		111607 ID1_HUMAN (12-161): 1.12e-51: 163: 37.42		K7EMM4_HUMAN (1-186): 1.21e-28: 108: 19.79
+	Hs
		551478 ID1_HUMAN (12-161): 1.12e-51: 163: 37.42		TFE2_HUMAN (1-186): 1.08e-26: 108: 18.52
+	Hs
		524547 ID1_HUMAN (12-161): 1.12e-51: 163: 37.42		LYL1_HUMAN (3-208): 1.11e-25: 102: 22.60
+	Mm
		589139 ID1_MOUSE (35-149): 7.26e-47: 152: 40.00		TAL1_MOUSE (32-212): 2.23e-29: 113: 24.87
+	Hs
		526743 ID2_HUMAN (1-148): 2.51e-41: 136: 43.24		MYF5_HUMAN (7-196): 5.16e-30: 113: 19.27
+	Hs
		551502 ID2_HUMAN (1-148): 2.51e-41: 136: 43.24		TFE2_HUMAN (1-186): 1.08e-26: 108: 18.52
+	Hs
		526744 ID3_HUMAN (1-135): 2.13e-33: 116: 44.44		MYF5_HUMAN (7-196): 5.16e-30: 113: 19.27
+	Mm
		781010 ID2_MOUSE (1-148): 1.17e-41: 137: 42.57		OLIG2_MOUSE (28-163): 2.86e-21: 91.5: 27.39
+	Hs
		551503 ID3_HUMAN (1-135): 2.13e-33: 116: 44.44		TFE2_HUMAN (1-186): 1.08e-26: 108: 18.52
+	Hs
		970566 ID2_HUMAN (1-148): 2.51e-41: 136: 43.24		OLIG2_HUMAN (28-165): 4.29e-20: 88: 26.28
+	Hs
		524557 ID3_HUMAN (1-135): 2.13e-33: 116: 44.44		LYL1_HUMAN (3-208): 1.11e-25: 102: 22.60
+	Dm
		509355 EMC_DROME (67-115): 6.12e-18: 78.5: 55.10		DA_DROME (11-211): 1.68e-25: 105: 18.23