HitPredict

Interactor 1: CRKL (P47941)
Crk-like protein
Gene: CRKL

Interactor 2: BCAR1 (Q61140)
Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas)
Gene: BCAR1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	8978305
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH3_1, SH3_1~SH3_1, SH3_1~SH3_2
Common GO terms	GO:0005829 - cytosol GO:0016477 - cell migration GO:0060326 - cell chemotaxis GO:0086100 - endothelin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Mm			1 874
+	Hs
		802811 CRKL_HUMAN (1-303): 3.37e-76: 236: 96.70		BCAR1_HUMAN (1-874): 5.26e-120: 386: 90.16
+	Hs
		802843 CRKL_HUMAN (1-303): 3.37e-76: 236: 96.70		CASL_HUMAN (1-872): 1.49e-112: 365: 35.77
+	Mm
		1142189 CRK_MOUSE (3-302): 1.23e-60: 196: 54.57		BCAR1_MOUSE (1-874): 3.19e-123: 395: 100.00
+	Rn
		1144370 CRK_RAT (3-302): 1.76e-60: 196: 54.26		BCAR1_RAT (4-874): 3.46e-121: 392: 96.90
+	Hs
		802545 CRK_HUMAN (3-302): 1.68e-60: 196: 54.57		BCAR1_HUMAN (1-874): 5.26e-120: 386: 90.16
+	Mm
		192348 CRK_MOUSE (3-302): 1.23e-60: 196: 54.57		CASL_MOUSE (1-872): 5.72e-114: 369: 36.09
+	Hs
		802600 CRK_HUMAN (3-302): 1.68e-60: 196: 54.57		CASL_HUMAN (1-872): 1.49e-112: 365: 35.77
+	Hs
		882224 GRB2_HUMAN (126-297): 7.67e-29: 111: 15.28		BCAR1_HUMAN (1-874): 5.26e-120: 386: 90.16
+	Hs
		802742 CRK_HUMAN (3-302): 1.68e-60: 196: 54.57		CASS4_HUMAN (4-869): 3.43e-51: 195: 22.02
+	Hs
		802885 CRKL_HUMAN (1-303): 3.37e-76: 236: 96.70		SH3K1_HUMAN (7-368): 6.95e-24: 109: 14.40
+	Hs
		802689 CRK_HUMAN (3-302): 1.68e-60: 196: 54.57		SH3K1_HUMAN (7-368): 6.95e-24: 109: 14.40
+	Hs
		199507 CRK_HUMAN (3-302): 1.68e-60: 196: 54.57		EFS_HUMAN (5-214): 2.33e-13: 75.7: 29.55
+	Hs
		554292 GRB2_HUMAN (126-297): 7.67e-29: 111: 15.28		MUC1_HUMAN (55-659): 1.32e-31: 135: 11.29
+	Mm
		1208602 PLCG2_MOUSE (3-192): 7.79e-29: 118: 18.54		SH3K1_MOUSE (7-368): 1.34e-23: 108: 15.49
+	Mm
		1141153 GRB2_MOUSE (126-297): 5.09e-29: 112: 15.28		SH3K1_MOUSE (7-368): 1.34e-23: 108: 15.49
+	Hs
		855816 VAV2_HUMAN (14-180): 5.44e-41: 153: 21.29		TITIN_HUMAN (68-419): 8.68e-10: 65.1: 13.12
+	Hs
		199502 PLCG1_HUMAN (3-202): 1.58e-29: 120: 19.44		EFS_HUMAN (5-214): 2.33e-13: 75.7: 29.55
+	Hs
		199510 GRB2_HUMAN (126-297): 7.67e-29: 111: 15.28		EFS_HUMAN (5-214): 2.33e-13: 75.7: 29.55
+	Hs
		203218 GRB2_HUMAN (126-297): 7.67e-29: 111: 15.28		SYNJ1_HUMAN (320-739): 2.9e-11: 69.9: 9.49
+	Hs
		924760 GRB2_HUMAN (126-297): 7.67e-29: 111: 15.28		PRG4_HUMAN (236-753): 8.16e-10: 64.9: 8.92