HitPredict

Interactor 1: TNFL6 (P48023)
Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]
Gene: FASLG

Interactor 2: GRAP (Q13588)
GRB2-related adapter protein
Gene: GRAP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11741599
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0007267 - cell-cell signaling
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 281 Hs			1 217
+	Hs
		815671 TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00		GRB2_HUMAN (1-216): 4.15e-69: 212: 59.72
+	Hs
		442792 TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00		HCK_HUMAN (4-158): 6.34e-52: 176: 32.74
+	Hs
		411638 TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00		LCK_HUMAN (4-204): 1.02e-41: 149: 26.98
+	Hs
		433285 TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00		YES_HUMAN (3-217): 1.29e-37: 138: 24.05
+	Hs
		433642 TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00		LYN_HUMAN (4-204): 4.34e-36: 134: 25.58
+	Hs
		454807 TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00		FGR_HUMAN (3-217): 2.98e-35: 132: 26.56
+	Hs
		557638 TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00		NCK1_HUMAN (5-145): 1.04e-23: 99: 35.47
+	Hs
		815714 TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00		ITSN2_HUMAN (106-215): 4.33e-14: 72.7: 24.11
+	Hs
		412082 TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00		FYN_HUMAN (154-215): 1.46e-12: 67.7: 31.25
+	Hs
		275179 TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00		GRAP2_HUMAN (3-55): 1.64e-11: 64.4: 33.96
+	Hs
		522855 TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00		SRC_HUMAN (141-214): 3.55e-11: 63.8: 21.05
+	Hs
		352447 TNFA_HUMAN (70-281): 3.29e-73: 225: 26.46		LYN_HUMAN (4-204): 4.34e-36: 134: 25.58
+	Hs
		352441 TNFA_HUMAN (70-281): 3.29e-73: 225: 26.46		FYN_HUMAN (154-215): 1.46e-12: 67.7: 31.25
+	Hs
		155678 TNF11_HUMAN (138-281): 1.95e-54: 180: 23.57		SRC_HUMAN (141-214): 3.55e-11: 63.8: 21.05