HitPredict

Interactor 1: TNFL6 (P48023)
Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]
Gene: FASLG

Interactor 2: PACN2 (Q9UNF0)
Protein kinase C and casein kinase substrate in neurons protein 2 (Syndapin-2) (Syndapin-II) (SdpII)
Gene: PACSIN2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	12023017, 24291222, 16318909
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005901 - caveola GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 281 Hs			1 486
+	Hs
		815712 TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00		PACN1_HUMAN (1-485): 3.17e-82: 263: 61.73
+	Hs
		815718 TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00		PACN3_HUMAN (6-485): 8.44e-67: 222: 41.04
+	Hs
		207781 TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00		PPIP1_HUMAN (9-485): 2.02e-55: 192: 18.67
+	Hs
		207808 Q53ZZ1_HUMAN (1-281): 1.11e-121: 350: 100.00		PPIP1_HUMAN (9-485): 2.02e-55: 192: 18.67
+	Mm
		780475 TNFL6_MOUSE (1-281): 1.01e-121: 350: 75.09		PPIP1_MOUSE (9-485): 3.28e-54: 189: 18.05
+	Hs
		815682 TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00		CIP4_HUMAN (12-465): 9.47e-47: 173: 15.03
+	Hs
		815708 TNFL6_HUMAN (1-281): 1.11e-121: 350: 100.00		FNBP1_HUMAN (12-397): 7.86e-42: 159: 15.01