HitPredict

Interactor 1: MTR1A (P48039)
Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor)
Gene: MTNR1A

Interactor 2: GBB4 (Q9HAV0)
Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4)
Gene: GNB4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.819

Property	Details
Experiments	26514267, 17215244
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	7tm_1~WD40
Common GO terms	GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 350 Hs			1 340
+	Hs
		429007 ADRB2_HUMAN (3-334): 5.8e-74: 236: 19.73		GBB2_HUMAN (1-340): 1.05e-110: 327: 90.00
+	Hs
		429130 ADRB2_HUMAN (3-334): 5.8e-74: 236: 19.73		GBB4_HUMAN (1-340): 1.76e-110: 326: 100.00
+	Hs
		815855 MTR1A_HUMAN (1-350): 1.56e-75: 238: 100.00		GBB1_HUMAN (1-340): 1.71e-106: 316: 90.88
+	Hs
		429006 ADRB2_HUMAN (3-334): 5.8e-74: 236: 19.73		GBB1_HUMAN (1-340): 1.71e-106: 316: 90.88
+	Hs
		825679 MTR1B_HUMAN (21-337): 3.11e-68: 219: 63.09		GBB2_HUMAN (1-340): 1.05e-110: 327: 90.00
+	Hs
		825746 MTR1B_HUMAN (21-337): 3.11e-68: 219: 63.09		GBB4_HUMAN (1-340): 1.76e-110: 326: 100.00
+	Rn
		495780 ADRB2_RAT (1-328): 1.98e-74: 237: 19.89		GNB5_RAT (129-340): 1.08e-42: 152: 23.53
+	Hs
		154652 DRD2_HUMAN (10-228): 8.22e-21: 94.7: 30.63		GNB5_HUMAN (129-340): 9.12e-43: 154: 23.08