HitPredict

Interactor 1: KCNJ4 (P48050)
Inward rectifier potassium channel 4 (HIRK2) (HRK1) (Hippocampal inward rectifier) (HIR) (Inward rectifier K(+) channel Kir2.3) (IRK-3) (Potassium channel, inwardly rectifying subfamily J member 4)
Gene: KCNJ4

Interactor 2: LIN7B (Q9HAP6)
Protein lin-7 homolog B (Lin-7B) (hLin7B) (Mammalian lin-seven protein 2) (MALS-2) (Vertebrate lin-7 homolog 2) (Veli-2) (hVeli2)
Gene: LIN7B

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	11742811
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016323 - basolateral plasma membrane GO:0030165 - PDZ domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 445 Hs			1 207
+	Hs
		816154 KCNJ4_HUMAN (1-445): 0: 690: 100.00		LIN7C_HUMAN (1-196): 9.63e-58: 182: 84.69
+	Hs
		158266 KCNJ4_HUMAN (1-445): 0: 690: 100.00		LIN7A_HUMAN (4-194): 1.18e-52: 170: 79.06
+	Hs
		1054726 KCJ12_HUMAN (7-445): 0: 660: 63.86		LIN7B_HUMAN (1-207): 8.65e-63: 195: 100.00
+	Hs
		1054728 KCJ12_HUMAN (7-445): 0: 660: 63.86		LIN7C_HUMAN (1-196): 9.63e-58: 182: 84.69
+	Hs
		158284 KCJ12_HUMAN (7-445): 0: 660: 63.86		LIN7A_HUMAN (4-194): 1.18e-52: 170: 79.06
+	Hs
		816148 KCNJ4_HUMAN (1-445): 0: 690: 100.00		SNTA1_HUMAN (19-206): 7.45e-32: 122: 23.67
+	Hs
		159173 KCNJ4_HUMAN (1-445): 0: 690: 100.00		CSKP_HUMAN (10-206): 4.77e-31: 121: 20.00
+	Hs
		1033871 KCJ12_HUMAN (7-445): 0: 660: 63.86		SNTB2_HUMAN (2-207): 1.48e-36: 135: 28.10
+	Hs
		816150 KCNJ4_HUMAN (1-445): 0: 690: 100.00		DLG2_HUMAN (89-202): 4.85e-25: 103: 29.41
+	Mm
		852403 KCNJ4_MOUSE (1-445): 0: 691: 96.86		DLG4_MOUSE (86-206): 2.01e-24: 102: 27.78
+	Hs
		816146 KCNJ4_HUMAN (1-445): 0: 690: 100.00		DLG4_HUMAN (86-206): 6.05e-24: 100: 27.78
+	Hs
		816147 KCNJ4_HUMAN (1-445): 0: 690: 100.00		DLG1_HUMAN (59-180): 1.67e-23: 99.4: 29.92
+	Hs
		1046429 KCJ12_HUMAN (7-445): 0: 660: 63.86		SNTB1_HUMAN (2-206): 4.53e-34: 128: 23.94
+	Hs
		1033833 KCJ12_HUMAN (7-445): 0: 660: 63.86		SNTA1_HUMAN (19-206): 7.45e-32: 122: 23.67
+	Hs
		159210 KCJ12_HUMAN (7-445): 0: 660: 63.86		CSKP_HUMAN (10-206): 4.77e-31: 121: 20.00
+	Hs
		1054723 KCJ12_HUMAN (7-445): 0: 660: 63.86		DLG2_HUMAN (89-202): 4.85e-25: 103: 29.41
+	Hs
		942342 KCJ12_HUMAN (7-445): 0: 660: 63.86		DLG4_HUMAN (86-206): 6.05e-24: 100: 27.78
+	Hs
		1021490 KCJ12_HUMAN (7-445): 0: 660: 63.86		DLG1_HUMAN (59-180): 1.67e-23: 99.4: 29.92
+	Mm
		1143540 Q9QYK8_MOUSE (9-439): 0: 657: 97.45		DLG4_MOUSE (86-206): 2.01e-24: 102: 27.78
+	Hs
		1054724 KCJ12_HUMAN (7-445): 0: 660: 63.86		DLG3_HUMAN (29-164): 2.29e-20: 90.3: 25.53