HitPredict

Interactor 1: LEPR (P48356)
Leptin receptor (LEP-R) (B219) (OB receptor) (OB-R) (CD antigen CD295)
Gene: LEPR

Interactor 2: CISH (Q62225)
Cytokine-inducible SH2-containing protein (CIS) (CIS-1) (Suppressor of cytokine signaling) (SOCS)
Gene: CISH

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.591

Property	Details
Experiments	16684815, 16698021
Identification Methods	affinity chromatography technology, transcriptional complementation assay, two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1162 Mm			1 257
+	Mm
		817307 LEPR_MOUSE (1-1162): 0: 1013: 100.00		SOCS7_MOUSE (42-255): 1.96e-50: 175: 25.69
+	Mm
		193361 LEPR_MOUSE (1-1162): 0: 1013: 100.00		SOCS2_MOUSE (41-257): 1.74e-50: 165: 37.33
+	Mm
		193379 LEPR_MOUSE (1-1162): 0: 1013: 100.00		SOCS3_MOUSE (51-253): 2.46e-47: 158: 29.67
+	Mm
		817309 LEPR_MOUSE (1-1162): 0: 1013: 100.00		SOCS6_MOUSE (69-255): 7.89e-42: 151: 29.10
+	Hs
		147403 LEPR_HUMAN (1-1162): 0: 962: 75.39		SOCS3_HUMAN (51-253): 6.82e-46: 154: 30.14
+	Hs
		817315 LEPR_HUMAN (1-1162): 0: 962: 75.39		GRB2_HUMAN (34-217): 2.53e-41: 143: 15.84
+	Hs
		412016 PTPRD_HUMAN (41-931): 6.81e-92: 327: 13.98		FYN_HUMAN (17-252): 7.56e-49: 170: 12.54
+	Hs
		411959 PTPRF_HUMAN (24-869): 2e-83: 301: 12.06		FYN_HUMAN (17-252): 7.56e-49: 170: 12.54
+	Mm
		56907 PTPRF_MOUSE (24-866): 4.53e-83: 300: 11.85		FYN_MOUSE (17-252): 7.56e-49: 170: 12.54
+	Hs
		411565 PTPRF_HUMAN (24-869): 2e-83: 301: 12.06		LCK_HUMAN (2-251): 3.47e-45: 160: 12.17
+	Hs
		434111 ROBO1_HUMAN (104-955): 1.93e-72: 267: 10.80		LYN_HUMAN (6-252): 1.98e-49: 171: 14.57
+	Dm
		337644 LAR_DROME (224-861): 3.81e-52: 203: 15.08		ABL_DROME (17-255): 1.73e-44: 161: 12.98
+	Hs
		433804 SDK2_HUMAN (207-864): 6.69e-23: 108: 11.24		LYN_HUMAN (6-252): 1.98e-49: 171: 14.57
+	Hs
		442787 IL6RB_HUMAN (426-883): 3.44e-16: 86: 14.75		HCK_HUMAN (4-252): 1.03e-52: 180: 13.77
+	Mm
		193384 IL6RB_MOUSE (268-883): 1.16e-17: 91.1: 13.57		SOCS3_MOUSE (51-253): 2.46e-47: 158: 29.67
+	Hs
		146590 PRLR_HUMAN (425-624): 5.8e-15: 81.7: 22.86		SOCS2_HUMAN (48-257): 1.58e-50: 165: 40.48
+	Hs
		147398 IL6RB_HUMAN (426-883): 3.44e-16: 86: 14.75		SOCS3_HUMAN (51-253): 6.82e-46: 154: 30.14
+	Hs
		147385 PRLR_HUMAN (425-624): 5.8e-15: 81.7: 22.86		SOCS3_HUMAN (51-253): 6.82e-46: 154: 30.14
+	Hs
		770194 IL6RB_HUMAN (426-883): 3.44e-16: 86: 14.75		GRB2_HUMAN (34-217): 2.53e-41: 143: 15.84
+	Hs
		655246 IL6RB_HUMAN (426-883): 3.44e-16: 86: 14.75		P85A_HUMAN (62-189): 5.55e-17: 82.2: 16.92