HitPredict

Interactor 1: LEPR (P48356)
Leptin receptor (LEP-R) (B219) (OB receptor) (OB-R) (CD antigen CD295)
Gene: LEPR

Interactor 2: SOCS6 (Q9JLY0)
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
Gene: SOCS6

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.50	0.417

Property	Details
Experiments	16698021
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1162 Mm			1 533
+	Mm
		193361 LEPR_MOUSE (1-1162): 0: 1013: 100.00		SOCS2_MOUSE (337-533): 2.15e-53: 181: 29.56
+	Mm
		817307 LEPR_MOUSE (1-1162): 0: 1013: 100.00		SOCS7_MOUSE (368-533): 9.8e-47: 173: 53.57
+	Mm
		817306 LEPR_MOUSE (1-1162): 0: 1013: 100.00		CISH_MOUSE (319-533): 1.25e-44: 159: 25.52
+	Mm
		193379 LEPR_MOUSE (1-1162): 0: 1013: 100.00		SOCS3_MOUSE (349-531): 1.35e-38: 142: 24.89
+	Hs
		147403 LEPR_HUMAN (1-1162): 0: 962: 75.39		SOCS3_HUMAN (349-531): 2.07e-37: 139: 25.81
+	Hs
		412016 PTPRD_HUMAN (41-931): 6.81e-92: 327: 13.98		FYN_HUMAN (258-504): 6.01e-55: 195: 14.06
+	Hs
		411959 PTPRF_HUMAN (24-869): 2e-83: 301: 12.06		FYN_HUMAN (258-504): 6.01e-55: 195: 14.06
+	Mm
		56907 PTPRF_MOUSE (24-866): 4.53e-83: 300: 11.85		FYN_MOUSE (258-504): 6.01e-55: 195: 14.06
+	Hs
		411565 PTPRF_HUMAN (24-869): 2e-83: 301: 12.06		LCK_HUMAN (260-493): 1.07e-52: 188: 17.21
+	Hs
		434111 ROBO1_HUMAN (104-955): 1.93e-72: 267: 10.80		LYN_HUMAN (279-493): 1.76e-50: 182: 16.60
+	Dm
		337644 LAR_DROME (224-861): 3.81e-52: 203: 15.08		ABL_DROME (358-506): 5.9e-31: 130: 26.67
+	Hs
		557632 DCC_HUMAN (133-950): 9.79e-67: 249: 14.22		NCK1_HUMAN (203-374): 1.02e-15: 81: 13.64
+	Hs
		442787 IL6RB_HUMAN (426-883): 3.44e-16: 86: 14.75		HCK_HUMAN (234-493): 5.36e-59: 205: 15.30
+	Hs
		433804 SDK2_HUMAN (207-864): 6.69e-23: 108: 11.24		LYN_HUMAN (279-493): 1.76e-50: 182: 16.60
+	Hs
		146590 PRLR_HUMAN (425-624): 5.8e-15: 81.7: 22.86		SOCS2_HUMAN (342-533): 1.26e-44: 158: 30.81
+	Hs
		560479 PRLR_HUMAN (425-624): 5.8e-15: 81.7: 22.86		CISH_HUMAN (329-533): 1.57e-43: 157: 26.27
+	Mm
		193384 IL6RB_MOUSE (268-883): 1.16e-17: 91.1: 13.57		SOCS3_MOUSE (349-531): 1.35e-38: 142: 24.89
+	Hs
		147398 IL6RB_HUMAN (426-883): 3.44e-16: 86: 14.75		SOCS3_HUMAN (349-531): 2.07e-37: 139: 25.81
+	Hs
		147385 PRLR_HUMAN (425-624): 5.8e-15: 81.7: 22.86		SOCS3_HUMAN (349-531): 2.07e-37: 139: 25.81
+	Hs
		655246 IL6RB_HUMAN (426-883): 3.44e-16: 86: 14.75		P85A_HUMAN (382-494): 6.52e-13: 73.6: 23.89