HitPredict

Interactor 1: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: SUMO1 (P63165)
Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1)
Gene: SUMO1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	25416956, 31515488
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016607 - nuclear speck
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 317 Hs			1 101
+	Hs
		817866 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36
+	Hs
		102151 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		SUMO5_HUMAN (1-101): 4.52e-41: 132: 88.12
+	Hs
		881792 SOX10_HUMAN (28-219): 8.75e-34: 130: 35.42		SUMO1_HUMAN (1-101): 1.01e-41: 134: 100.00
+	Hs
		928079 SSRP1_HUMAN (24-203): 1.77e-31: 125: 15.68		SUMO1_HUMAN (1-101): 1.01e-41: 134: 100.00
+	Hs
		902722 CIC_HUMAN (3-272): 8.9e-33: 130: 22.26		SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36
+	Rn
		223217 SOX10_RAT (13-272): 2.43e-31: 124: 26.81		SUMO3_RAT (1-100): 1.5e-39: 128: 46.00
+	Hs
		902545 SSRP1_HUMAN (24-203): 1.77e-31: 125: 15.68		SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36
+	Hs
		727841 SOX6_HUMAN (29-244): 2.42e-29: 120: 23.61		SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36