HitPredict

Interactor 1: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: TFAM (Q00059)
Transcription factor A, mitochondrial (mtTFA) (Mitochondrial transcription factor 1) (MtTF1) (Transcription factor 6) (TCF-6) (Transcription factor 6-like 2)
Gene: TFAM

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	35140242, 34732716
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HMG_box~HMG_box, HMG_box~HMG_box_2
Common GO terms	GO:0000976 - transcription cis-regulatory region binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0043565 - sequence-specific DNA binding GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 317 Hs			1 246
+	Hs
		727727 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		TFAM_HUMAN (1-246): 1.85e-62: 197: 100.00
+	Hs
		727836 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SOX6_HUMAN (49-160): 2.17e-25: 106: 12.82
+	Hs
		727709 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SOX5_HUMAN (49-150): 1.14e-23: 101: 12.75
+	Hs
		818487 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		HM20A_HUMAN (45-146): 3.64e-24: 100: 19.61
+	Hs
		313690 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SOX14_HUMAN (150-235): 8.56e-24: 97.5: 22.22
+	Hs
		782193 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SOX3_HUMAN (124-224): 6.52e-22: 95.6: 18.10
+	Hs
		817845 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SOX8_HUMAN (138-244): 1.96e-19: 88.3: 17.12
+	Hs
		818669 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SOX21_HUMAN (153-234): 2.41e-13: 69.8: 22.09
+	Hs
		567658 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		UBF1_HUMAN (51-214): 4.22e-11: 64.4: 20.46
+	Hs
		727705 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		SOX6_HUMAN (49-160): 2.17e-25: 106: 12.82
+	Mm
		727702 SOX5_MOUSE (2-127): 2.19e-42: 157: 40.48		SOX6_MOUSE (49-160): 4.99e-25: 105: 12.82
+	Hs
		727704 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		SOX5_HUMAN (49-150): 1.14e-23: 101: 12.75
+	Hs
		727808 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		HM20A_HUMAN (45-146): 3.64e-24: 100: 19.61
+	Hs
		782191 SOX3_HUMAN (1-317): 1.78e-44: 159: 46.42		SOX3_HUMAN (124-224): 6.52e-22: 95.6: 18.10
+	Hs
		727795 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		SOX7_HUMAN (121-230): 1.71e-22: 96.4: 14.91
+	Dm
		115539 M9PFG6_DROME (21-121): 2.56e-40: 147: 78.22		DICH_DROME (137-227): 4.13e-23: 98.3: 22.11
+	Dm
		114544 M9PFG6_DROME (21-121): 2.56e-40: 147: 78.22		M9PCZ7_DROME (147-224): 1.88e-22: 97.5: 25.61
+	Hs
		727827 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		SOX13_HUMAN (142-226): 5.28e-17: 81.7: 14.61
+	Hs
		225791 HM20A_HUMAN (6-248): 2.71e-37: 137: 15.32		SOX15_HUMAN (115-231): 7.87e-21: 89.4: 15.70