HitPredict

Interactor 1: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: PB1 (Q86U86)
Protein polybromo-1 (hPB1) (BRG1-associated factor 180) (BAF180) (Polybromo-1D)
Gene: PBRM1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HMG_box~HMG_box
Common GO terms	GO:0000785 - chromatin GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045597 - positive regulation of cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 317 Hs			1 1689
+	Hs
		818817 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		PB1_HUMAN (1-1689): 0: 1223: 100.00
+	Hs
		1199196 SOX17_HUMAN (7-260): 1.35e-34: 132: 28.19		PB1_HUMAN (1-1689): 0: 1223: 100.00
+	Hs
		881814 SOX10_HUMAN (28-219): 8.75e-34: 130: 35.42		PB1_HUMAN (1-1689): 0: 1223: 100.00
+	Hs
		1199188 SOX7_HUMAN (23-299): 8.76e-34: 129: 27.03		PB1_HUMAN (1-1689): 0: 1223: 100.00
+	Xl
		945609 SSRP1_XENLA (21-188): 2.73e-34: 134: 16.19		P79922_XENLA (585-1361): 7.33e-72: 268: 13.31
+	Hs
		600209 CIC_HUMAN (3-272): 8.9e-33: 130: 22.26		TAF1_HUMAN (457-963): 1.08e-57: 223: 16.79
+	Hs
		818450 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		BRD8_HUMAN (301-506): 2.43e-17: 90.8: 14.55
+	Hs
		1067153 HM20A_HUMAN (6-248): 2.71e-37: 137: 15.32		BRD3_HUMAN (358-959): 6.75e-48: 186: 12.76
+	Hs
		817810 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SMCA4_HUMAN (764-881): 7.55e-11: 69.5: 23.58
+	Hs
		817809 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SMCA2_HUMAN (794-881): 2.15e-09: 64.9: 26.09
+	Mm
		818702 SOX2_MOUSE (1-317): 8.01e-72: 226: 94.67		SMCA4_MOUSE (748-881): 2.04e-12: 74.9: 23.19
+	Hs
		818785 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		SMCA4_HUMAN (764-881): 7.55e-11: 69.5: 23.58
+	Mm
		1111947 NSD2_MOUSE (10-255): 7.97e-34: 133: 11.16		SMCA4_MOUSE (748-881): 2.04e-12: 74.9: 23.19
+	Hs
		818784 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		SMCA2_HUMAN (794-881): 2.15e-09: 64.9: 26.09
+	Hs
		847058 CIC_HUMAN (3-272): 8.9e-33: 130: 22.26		SMCA4_HUMAN (764-881): 7.55e-11: 69.5: 23.58
+	Hs
		846943 SOX4_HUMAN (9-289): 2.6e-33: 129: 26.69		SMCA4_HUMAN (764-881): 7.55e-11: 69.5: 23.58
+	Hs
		847069 SOX7_HUMAN (23-299): 8.76e-34: 129: 27.03		SMCA4_HUMAN (764-881): 7.55e-11: 69.5: 23.58
+	Hs
		846868 SOX17_HUMAN (7-260): 1.35e-34: 132: 28.19		SMCA2_HUMAN (794-881): 2.15e-09: 64.9: 26.09
+	Hs
		846730 SOX10_HUMAN (28-219): 8.75e-34: 130: 35.42		SMCA2_HUMAN (794-881): 2.15e-09: 64.9: 26.09
+	Hs
		846863 SOX7_HUMAN (23-299): 8.76e-34: 129: 27.03		SMCA2_HUMAN (794-881): 2.15e-09: 64.9: 26.09