HitPredict

Interactor 1: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: MINT (Q96T58)
Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)
Gene: SPEN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	28794006, 23667531
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 317 Hs			1 3664
+	Hs
		817926 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		TIAR_HUMAN (321-515): 4.05e-44: 168: 21.08
+	Hs
		680429 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		TIA1_HUMAN (293-512): 4.75e-41: 159: 17.47
+	Mm
		818677 SOX2_MOUSE (1-317): 8.01e-72: 226: 94.67		TIA1_MOUSE (293-512): 1.64e-37: 149: 17.47
+	Hs
		817913 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		MAP1A_HUMAN (1594-3632): 5.67e-29: 131: 8.94
+	Hs
		818011 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		PABP4_HUMAN (6-131): 2.64e-15: 84.9: 15.03
+	Hs
		818381 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		RBM15_HUMAN (3336-3649): 5.22e-14: 81.1: 26.65
+	Hs
		311835 HM20B_HUMAN (11-249): 2.15e-33: 126: 17.77		TACC2_HUMAN (1620-3617): 6.71e-28: 127: 8.53
+	Hs
		727830 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		PRC2C_HUMAN (1490-3644): 8.69e-16: 87.2: 7.55
+	Hs
		727947 SOX6_HUMAN (29-244): 2.42e-29: 120: 23.61		PRC2C_HUMAN (1490-3644): 8.69e-16: 87.2: 7.55
+	Hs
		996849 SSRP1_HUMAN (24-203): 1.77e-31: 125: 15.68		RBM15_HUMAN (3336-3649): 5.22e-14: 81.1: 26.65