HitPredict

Interactor 1: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: SP130 (Q9H0E3)
Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130)
Gene: SAP130

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	28794006, 35140242, 23667531
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0016607 - nuclear speck
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 317 Hs			1 1048
+	Hs
		727801 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		SP130_HUMAN (1-1048): 2.19e-131: 426: 100.00
+	Hs
		1300934 CIC_HUMAN (3-272): 8.9e-33: 130: 22.26		SP130_HUMAN (1-1048): 2.19e-131: 426: 100.00
+	Hs
		727920 SOX6_HUMAN (29-244): 2.42e-29: 120: 23.61		SP130_HUMAN (1-1048): 2.19e-131: 426: 100.00
+	Hs
		818373 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		CIC_HUMAN (284-939): 3.09e-10: 67: 10.76
+	Hs
		817913 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		MAP1A_HUMAN (7-679): 5.66e-09: 62.8: 8.31
+	Hs
		818266 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		KMT2C_HUMAN (364-832): 7.84e-09: 62.5: 15.83
+	Hs
		996722 SSRP1_HUMAN (24-203): 1.77e-31: 125: 15.68		ANR11_HUMAN (121-1011): 3.96e-42: 171: 12.56
+	Hs
		1056996 TF7L2_HUMAN (14-255): 5.81e-35: 135: 19.75		MDC1_HUMAN (11-926): 1.17e-29: 130: 9.43
+	Hs
		331812 NSD2_HUMAN (7-251): 1.34e-29: 120: 10.71		MDC1_HUMAN (11-926): 1.17e-29: 130: 9.43
+	Hs
		727788 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		CIC_HUMAN (284-939): 3.09e-10: 67: 10.76
+	Hs
		818837 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		CIC_HUMAN (284-939): 3.09e-10: 67: 10.76
+	Hs
		818819 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		KMT2C_HUMAN (364-832): 7.84e-09: 62.5: 15.83
+	Hs
		1300941 SOX17_HUMAN (7-260): 1.35e-34: 132: 28.19		CIC_HUMAN (284-939): 3.09e-10: 67: 10.76
+	Hs
		881826 SOX10_HUMAN (28-219): 8.75e-34: 130: 35.42		CIC_HUMAN (284-939): 3.09e-10: 67: 10.76
+	Hs
		1243843 SOX17_HUMAN (7-260): 1.35e-34: 132: 28.19		KMT2C_HUMAN (364-832): 7.84e-09: 62.5: 15.83
+	Hs
		996845 SSRP1_HUMAN (24-203): 1.77e-31: 125: 15.68		CIC_HUMAN (284-939): 3.09e-10: 67: 10.76
+	Hs
		1243837 SOX7_HUMAN (23-299): 8.76e-34: 129: 27.03		KMT2C_HUMAN (364-832): 7.84e-09: 62.5: 15.83
+	Hs
		727910 SOX6_HUMAN (29-244): 2.42e-29: 120: 23.61		CIC_HUMAN (284-939): 3.09e-10: 67: 10.76
+	Hs
		225775 SOX15_HUMAN (13-118): 1.78e-31: 119: 66.04		CIC_HUMAN (284-939): 3.09e-10: 67: 10.76