HitPredict

Interactor 1: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: TCF20 (Q9UGU0)
Transcription factor 20 (TCF-20) (Nuclear factor SPBP) (Protein AR1) (Stromelysin-1 PDGF-responsive element-binding protein) (SPRE-binding protein)
Gene: TCF20

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	28794006, 35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 317 Hs			1 1960
+	Hs
		727820 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		TCF20_HUMAN (1-1960): 0: 925: 100.00
+	Hs
		1342345 HM20A_HUMAN (6-248): 2.71e-37: 137: 15.32		TCF20_HUMAN (1-1960): 0: 925: 100.00
+	Hs
		1332328 SOX17_HUMAN (7-260): 1.35e-34: 132: 28.19		TCF20_HUMAN (1-1960): 0: 925: 100.00
+	Hs
		1311937 SOX7_HUMAN (23-299): 8.76e-34: 129: 27.03		TCF20_HUMAN (1-1960): 0: 925: 100.00
+	Mm
		1322170 HM20A_MOUSE (6-248): 5.08e-37: 137: 15.32		TCF20_MOUSE (1-1960): 0: 860: 89.91
+	Hs
		1191026 HM20A_HUMAN (6-248): 2.71e-37: 137: 15.32		RAI1_HUMAN (1-1933): 2.26e-103: 371: 20.28
+	Mm
		1143137 HM20A_MOUSE (6-248): 5.08e-37: 137: 15.32		RAI1_MOUSE (1-1933): 5.16e-102: 367: 19.85
+	Hs
		817951 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		KMT2A_HUMAN (1765-1933): 1.16e-32: 142: 20.00
+	Hs
		257583 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		ANR17_HUMAN (6-473): 7.33e-11: 70.2: 10.33
+	Hs
		152610 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		KMT2D_HUMAN (207-917): 2.24e-09: 65.3: 9.99
+	Hs
		818266 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		KMT2C_HUMAN (307-902): 2.88e-09: 64.9: 11.15
+	Hs
		152602 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		KMT2D_HUMAN (207-917): 2.24e-09: 65.3: 9.99
+	Hs
		152611 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		KMT2D_HUMAN (207-917): 2.24e-09: 65.3: 9.99
+	Hs
		818819 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		KMT2C_HUMAN (307-902): 2.88e-09: 64.9: 11.15
+	Hs
		152690 SOX17_HUMAN (7-260): 1.35e-34: 132: 28.19		KMT2D_HUMAN (207-917): 2.24e-09: 65.3: 9.99
+	Hs
		1243843 SOX17_HUMAN (7-260): 1.35e-34: 132: 28.19		KMT2C_HUMAN (307-902): 2.88e-09: 64.9: 11.15
+	Hs
		867119 CIC_HUMAN (3-272): 8.9e-33: 130: 22.26		SC24C_HUMAN (143-516): 5.55e-10: 66.9: 16.14
+	Hs
		152619 SOX10_HUMAN (28-219): 8.75e-34: 130: 35.42		KMT2D_HUMAN (207-917): 2.24e-09: 65.3: 9.99
+	Hs
		152684 SOX7_HUMAN (23-299): 8.76e-34: 129: 27.03		KMT2D_HUMAN (207-917): 2.24e-09: 65.3: 9.99
+	Hs
		1243837 SOX7_HUMAN (23-299): 8.76e-34: 129: 27.03		KMT2C_HUMAN (307-902): 2.88e-09: 64.9: 11.15