HitPredict

Interactor 1: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: RCOR1 (Q9UKL0)
REST corepressor 1 (Protein CoREST)
Gene: RCOR1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	28794006
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 317 Hs			1 485
+	Hs
		818553 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		RCOR3_HUMAN (105-480): 6.86e-123: 369: 63.08
+	Hs
		727824 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		RCOR1_HUMAN (1-485): 5.94e-148: 433: 100.00
+	Mm
		818741 SOX2_MOUSE (1-317): 8.01e-72: 226: 94.67		RCOR2_MOUSE (70-482): 3.32e-110: 338: 53.19
+	Hs
		818412 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		MTA3_HUMAN (80-485): 5.88e-92: 293: 17.42
+	Hs
		727817 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		RCOR3_HUMAN (105-480): 6.86e-123: 369: 63.08
+	Hs
		818012 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		MTA1_HUMAN (81-410): 5.09e-71: 241: 16.03
+	Mm
		101612 Q60I23_MOUSE (1-317): 7.89e-75: 234: 96.24		F8VQL9_MOUSE (141-474): 2.64e-70: 245: 20.00
+	Mm
		101824 Q60I23_MOUSE (1-317): 7.89e-75: 234: 96.24		F8WHY8_MOUSE (81-410): 7.3e-70: 237: 15.76
+	Hs
		818368 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		TREF1_HUMAN (47-410): 7.44e-63: 223: 17.28
+	Hs
		295961 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		MTA2_HUMAN (85-446): 1.69e-64: 222: 16.67
+	Mm
		1142022 Q60I23_MOUSE (1-317): 7.89e-75: 234: 96.24		MTA2_MOUSE (80-446): 3.08e-65: 224: 16.46
+	Hs
		818240 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		MIER1_HUMAN (37-403): 4.3e-63: 215: 16.67
+	Hs
		727796 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		MTA3_HUMAN (80-485): 5.88e-92: 293: 17.42
+	Mm
		818740 SOX2_MOUSE (1-317): 8.01e-72: 226: 94.67		TREF1_MOUSE (17-410): 1.24e-62: 222: 17.16
+	Hs
		818169 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		MDEAS_HUMAN (105-381): 6.79e-46: 173: 16.67
+	Hs
		818811 SOX9_HUMAN (28-260): 2.6e-37: 140: 27.57		MDEAS_HUMAN (105-381): 6.79e-46: 173: 16.67
+	Hs
		261435 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		NCOR1_HUMAN (194-465): 5.18e-11: 67.4: 12.86
+	Hs
		818668 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		NCOR2_HUMAN (194-380): 9.4e-09: 60.4: 12.11
+	Hs
		261421 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		NCOR1_HUMAN (194-465): 5.18e-11: 67.4: 12.86
+	Hs
		727832 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		NCOR2_HUMAN (194-380): 9.4e-09: 60.4: 12.11