HitPredict

Interactor 1: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: MACF1 (Q9UPN3)
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)
Gene: MACF1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	23667531
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 317 Hs			1 7388
+	Hs
		506811 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SPTB1_HUMAN (3013-4737): 1.1e-28: 131: 8.92
+	Hs
		551635 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		DESP_HUMAN (2737-3775): 9.21e-27: 124: 8.65
+	Hs
		818070 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		PLEC_HUMAN (2677-3656): 8.53e-27: 124: 8.13
+	Hs
		164582 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SPTN2_HUMAN (3436-4815): 1.06e-11: 74.8: 9.59
+	Hs
		817925 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Mm
		82750 SOX2_MOUSE (1-317): 8.01e-72: 226: 94.67		B9EKJ1_MOUSE (433-1344): 4.47e-09: 66.1: 13.69
+	Hs
		885297 CIC_HUMAN (3-272): 8.9e-33: 130: 22.26		EPIPL_HUMAN (1538-2789): 1.49e-35: 154: 13.15
+	Mm
		93555 SOX17_MOUSE (7-290): 2.02e-35: 134: 27.59		DESP_MOUSE (2737-3805): 1.11e-27: 127: 8.89
+	Hs
		551812 CIC_HUMAN (3-272): 8.9e-33: 130: 22.26		DESP_HUMAN (2737-3775): 9.21e-27: 124: 8.65
+	Hs
		331816 NSD2_HUMAN (7-251): 1.34e-29: 120: 10.71		PLEC_HUMAN (2677-3656): 8.53e-27: 124: 8.13
+	Hs
		963398 CIC_HUMAN (3-272): 8.9e-33: 130: 22.26		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Hs
		521599 CIC_HUMAN (3-272): 8.9e-33: 130: 22.26		ACTN1_HUMAN (921-1398): 1.47e-10: 70.5: 9.07