HitPredict

Interactor 1: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: SMC3 (Q9UQE7)
Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP)
Gene: SMC3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	28794006, 35140242, 23667531
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 317 Hs			1 1217
+	Mm
		818763 SOX2_MOUSE (1-317): 8.01e-72: 226: 94.67		SMC3_MOUSE (1-1217): 1.1e-124: 416: 99.92
+	Hs
		1301004 CIC_HUMAN (3-272): 8.9e-33: 130: 22.26		SMC3_HUMAN (1-1217): 1.81e-124: 415: 100.00
+	Hs
		818047 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SMC1A_HUMAN (2-1211): 5.21e-79: 286: 16.36
+	Mm
		818762 SOX2_MOUSE (1-317): 8.01e-72: 226: 94.67		SMC1A_MOUSE (2-1211): 3.28e-79: 286: 16.44
+	Hs
		311503 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		SMC2_HUMAN (1-1217): 1.65e-73: 269: 19.14
+	Hs
		1057362 CIC_HUMAN (3-272): 8.9e-33: 130: 22.26		SMC1A_HUMAN (2-1211): 5.21e-79: 286: 16.36