HitPredict

Interactor 1: SOX2 (P48432)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: CBX5 (Q61686)
Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	31077711
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 319 Mm			1 191
+	Mm
		818771 SOX2_MOUSE (1-319): 3.85e-64: 207: 100.00		Q9DCC5_MOUSE (1-181): 4.97e-62: 192: 60.22
+	Mm
		818693 SOX2_MOUSE (1-319): 3.85e-64: 207: 100.00		CBX1_MOUSE (26-180): 3.2e-56: 177: 64.74
+	Hs
		800501 CIC_HUMAN (10-274): 4.32e-43: 160: 23.83		CBX5_HUMAN (1-191): 2.88e-69: 210: 97.91
+	Hs
		1027207 CIC_HUMAN (10-274): 4.32e-43: 160: 23.83		CBX3_HUMAN (1-181): 4.97e-62: 192: 60.22
+	Hs
		1027152 BBX_HUMAN (31-255): 1.96e-35: 137: 19.13		CBX3_HUMAN (1-181): 4.97e-62: 192: 60.22
+	Hs
		1027280 TF7L2_HUMAN (46-269): 1.49e-35: 137: 17.78		CBX3_HUMAN (1-181): 4.97e-62: 192: 60.22
+	Hs
		996646 SSRP1_HUMAN (21-205): 1.2e-33: 132: 15.14		CBX3_HUMAN (1-181): 4.97e-62: 192: 60.22
+	Hs
		123201 SOX2_HUMAN (1-319): 2.01e-64: 207: 94.67		CBX4_HUMAN (11-125): 2.1e-27: 109: 25.22
+	Hs
		331801 NSD2_HUMAN (1-288): 5.77e-29: 119: 11.04		CBX3_HUMAN (1-181): 4.97e-62: 192: 60.22
+	Hs
		818053 SOX2_HUMAN (1-319): 2.01e-64: 207: 94.67		CBX2_HUMAN (10-109): 8.73e-25: 102: 32.00
+	Dm
		1363173 Q9VUD3_DROME (13-165): 1.58e-35: 136: 52.29		Q9VCU6_DROME (15-170): 2.53e-47: 156: 35.03
+	Dm
		114467 M9PCG2_DROME (13-165): 1.35e-34: 134: 52.29		Q9VCU6_DROME (15-170): 2.53e-47: 156: 35.03
+	Hs
		567688 UBF1_HUMAN (1-132): 8.57e-13: 70.9: 20.00		CBX3_HUMAN (1-181): 4.97e-62: 192: 60.22
+	Hs
		727806 SOX5_HUMAN (17-129): 1.56e-39: 149: 40.71		CBX8_HUMAN (11-88): 8.14e-25: 100: 34.62
+	Hs
		316171 TF7L2_HUMAN (46-269): 1.49e-35: 137: 17.78		CBX6_HUMAN (11-119): 5.27e-25: 101: 25.98
+	Hs
		996672 SSRP1_HUMAN (21-205): 1.2e-33: 132: 15.14		CBX2_HUMAN (10-109): 8.73e-25: 102: 32.00