HitPredict

Interactor 1: SOX9 (P48436)
Transcription factor SOX-9
Gene: SOX9

Interactor 2: NCOA3 (Q9Y6Q9)
Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)
Gene: NCOA3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032991 - protein-containing complex GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Hs			1 1424
+	Hs
		225814 SOX15_HUMAN (103-267): 7.9e-41: 148: 37.57		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		727952 SOX6_HUMAN (94-296): 5.82e-34: 138: 25.98		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		881838 SOX10_HUMAN (10-509): 6.13e-34: 135: 45.90		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		818674 SOX2_HUMAN (73-381): 8.71e-33: 129: 23.81		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		225746 SOX15_HUMAN (103-267): 7.9e-41: 148: 37.57		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		996797 SSRP1_HUMAN (5-263): 2.08e-31: 130: 16.29		BMAL2_HUMAN (10-541): 1.06e-108: 360: 16.06
+	Hs
		727872 SOX6_HUMAN (94-296): 5.82e-34: 138: 25.98		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		881806 SOX10_HUMAN (10-509): 6.13e-34: 135: 45.90		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		126174 HM20A_HUMAN (13-227): 2.33e-34: 134: 16.30		BMAL1_HUMAN (6-541): 4.9e-105: 349: 18.23
+	Hs
		818079 SOX2_HUMAN (73-381): 8.71e-33: 129: 23.81		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		881827 SOX10_HUMAN (10-509): 6.13e-34: 135: 45.90		EPAS1_HUMAN (12-878): 3.88e-100: 343: 13.27
+	Dm
		404413 DICH_DROME (98-237): 9.44e-41: 152: 38.46		SIM_DROME (27-526): 1.14e-89: 309: 17.16
+	Hs
		1050581 CIC_HUMAN (20-342): 1.93e-36: 146: 21.74		SIM2_HUMAN (27-690): 1.22e-88: 305: 14.79
+	Hs
		649145 CIC_HUMAN (20-342): 1.93e-36: 146: 21.74		ARNT_HUMAN (6-642): 2.95e-76: 272: 16.01
+	Hs
		181564 HM20A_HUMAN (13-227): 2.33e-34: 134: 16.30		CLOCK_HUMAN (1-791): 2.47e-78: 279: 13.73
+	Hs
		649051 SOX6_HUMAN (94-296): 5.82e-34: 138: 25.98		ARNT_HUMAN (6-642): 2.95e-76: 272: 16.01
+	Hs
		181503 SOX2_HUMAN (73-381): 8.71e-33: 129: 23.81		CLOCK_HUMAN (1-791): 2.47e-78: 279: 13.73
+	Hs
		649066 SOX2_HUMAN (73-381): 8.71e-33: 129: 23.81		ARNT_HUMAN (6-642): 2.95e-76: 272: 16.01
+	Hs
		818819 SOX9_HUMAN (1-509): 1.74e-67: 227: 100.00		KMT2C_HUMAN (471-1383): 2.87e-11: 70.9: 12.87
+	Hs
		818266 SOX2_HUMAN (73-381): 8.71e-33: 129: 23.81		KMT2C_HUMAN (471-1383): 2.87e-11: 70.9: 12.87