HitPredict

Interactor 1: RXRG (P48443)
Retinoic acid receptor RXR-gamma (Nuclear receptor subfamily 2 group B member 3) (Retinoid X receptor gamma)
Gene: RXRG

Interactor 2: Q86UC5 (Q86UC5)
Retinoic acid receptor beta (Nuclear receptor subfamily 1 group B member 2)
Gene: RARB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	31515488
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms	GO:0004879 - nuclear receptor activity GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding GO:0048384 - retinoic acid receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 463 Hs			1 346
+	Hs
		500357 RXRG_HUMAN (1-463): 2.45e-178: 508: 100.00		RARB_HUMAN (1-346): 5.19e-116: 345: 99.71
+	Hs
		587136 RXRG_HUMAN (1-463): 2.45e-178: 508: 100.00		RXRA_HUMAN (1-308): 7.37e-105: 317: 31.07
+	Hs
		500468 RXRG_HUMAN (1-463): 2.45e-178: 508: 100.00		THB_HUMAN (1-307): 1.61e-103: 313: 34.84
+	Mm
		659752 RXRG_MOUSE (1-463): 3.96e-178: 508: 98.27		THB_MOUSE (1-307): 1.1e-102: 311: 33.93
+	Hs
		487920 RXRG_HUMAN (1-463): 2.45e-178: 508: 100.00		RARA_HUMAN (1-315): 2.13e-96: 295: 86.98
+	Hs
		530789 RXRG_HUMAN (1-463): 2.45e-178: 508: 100.00		RARG_HUMAN (1-338): 1.33e-96: 295: 79.88
+	Hs
		611397 RXRG_HUMAN (1-463): 2.45e-178: 508: 100.00		NR4A1_HUMAN (1-308): 1.37e-83: 266: 32.80
+	Hs
		490054 RXRG_HUMAN (1-463): 2.45e-178: 508: 100.00		NR2F6_HUMAN (2-312): 6.98e-82: 256: 27.19
+	Hs
		818871 RXRG_HUMAN (1-463): 2.45e-178: 508: 100.00		NR1H3_HUMAN (1-309): 1.57e-80: 254: 28.49
+	Mm
		659756 RXRG_MOUSE (1-463): 3.96e-178: 508: 98.27		NR1H3_MOUSE (1-309): 2.24e-80: 253: 29.70
+	Mm
		509288 RXRA_MOUSE (1-463): 1.09e-154: 448: 68.78		RARA_MOUSE (1-318): 6.62e-97: 296: 86.48
+	Mm
		659754 RXRG_MOUSE (1-463): 3.96e-178: 508: 98.27		NR1H2_MOUSE (1-309): 2.66e-40: 148: 29.51
+	Hs
		818870 RXRG_HUMAN (1-463): 2.45e-178: 508: 100.00		PPARA_HUMAN (1-307): 3.16e-35: 135: 28.41
+	Hs
		818867 RXRG_HUMAN (1-463): 2.45e-178: 508: 100.00		NR1H2_HUMAN (119-309): 5.07e-34: 132: 37.50
+	Hs
		93999 RXRG_HUMAN (1-463): 2.45e-178: 508: 100.00		F1D8P7_HUMAN (119-309): 3.53e-34: 132: 37.50
+	Hs
		740462 RXRG_HUMAN (1-463): 2.45e-178: 508: 100.00		PPARG_HUMAN (1-307): 1.11e-33: 131: 28.61
+	Hs
		818868 RXRG_HUMAN (1-463): 2.45e-178: 508: 100.00		PPARD_HUMAN (1-307): 7.7e-34: 131: 26.72
+	Hs
		818885 RXRG_HUMAN (1-463): 2.45e-178: 508: 100.00		NR1H4_HUMAN (1-291): 4.72e-33: 129: 30.38
+	Mm
		659751 RXRG_MOUSE (1-463): 3.96e-178: 508: 98.27		PPARD_MOUSE (1-307): 1.1e-32: 128: 26.72
+	Mm
		613149 RXRA_MOUSE (1-463): 1.09e-154: 448: 68.78		PPARA_MOUSE (1-307): 1.68e-36: 139: 28.82