HitPredict

Interactor 1: PP2BC (P48454)
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin, testis-specific catalytic subunit) (Calmodulin-dependent calcineurin A subunit gamma isoform)
Gene: PPP3CC

Interactor 2: GSK3A (P49840)
Glycogen synthase kinase-3 alpha (GSK-3 alpha) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3A) (EC 2.7.11.1)
Gene: GSK3A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 512 Hs			1 483
+	Hs
		835347 PP2BA_HUMAN (6-512): 0: 826: 80.59		GSK3A_HUMAN (16-483): 7.48e-155: 450: 100.00
+	Hs
		819139 PP2BC_HUMAN (1-512): 0: 844: 100.00		GSK3B_HUMAN (65-471): 1.58e-145: 424: 76.41
+	Hs
		835697 PP2BA_HUMAN (6-512): 0: 826: 80.59		GSK3B_HUMAN (65-471): 1.58e-145: 424: 76.41
+	Hs
		557527 PP2BB_HUMAN (12-504): 0: 793: 82.66		GSK3A_HUMAN (16-483): 7.48e-155: 450: 100.00
+	Xl
		724507 Q6AXB0_XENLA (1-512): 0: 811: 77.67		CDK1A_XENLA (116-412): 1.11e-133: 390: 31.48
+	Hs
		737656 PP1G_HUMAN (33-347): 7.16e-171: 486: 35.60		GSK3A_HUMAN (16-483): 7.48e-155: 450: 100.00
+	Hs
		835302 PP1A_HUMAN (33-333): 8.53e-171: 486: 35.48		GSK3A_HUMAN (16-483): 7.48e-155: 450: 100.00
+	Hs
		835316 PP2AA_HUMAN (38-334): 3.44e-169: 481: 39.47		GSK3A_HUMAN (16-483): 7.48e-155: 450: 100.00
+	Hs
		625180 PP1G_HUMAN (33-347): 7.16e-171: 486: 35.60		CDK2_HUMAN (116-413): 1.52e-147: 425: 32.03
+	Hs
		625299 PP1A_HUMAN (33-333): 8.53e-171: 486: 35.48		CDK2_HUMAN (116-413): 1.52e-147: 425: 32.03
+	Hs
		737657 PP1G_HUMAN (33-347): 7.16e-171: 486: 35.60		GSK3B_HUMAN (65-471): 1.58e-145: 424: 76.41
+	Hs
		835631 PP1A_HUMAN (33-333): 8.53e-171: 486: 35.48		GSK3B_HUMAN (65-471): 1.58e-145: 424: 76.41
+	Mm
		906388 PP1A_MOUSE (33-333): 5.51e-171: 487: 35.48		GSK3B_MOUSE (65-471): 4.7e-145: 423: 75.92
+	Mm
		926537 PP1G_MOUSE (33-341): 5.88e-171: 486: 35.96		GSK3A_MOUSE (16-483): 1.86e-144: 424: 93.05
+	Hs
		625340 PP2AA_HUMAN (38-334): 3.44e-169: 481: 39.47		CDK2_HUMAN (116-413): 1.52e-147: 425: 32.03
+	Hs
		835644 PP2AA_HUMAN (38-334): 3.44e-169: 481: 39.47		GSK3B_HUMAN (65-471): 1.58e-145: 424: 76.41
+	Mm
		93773 PP1A_MOUSE (33-333): 5.51e-171: 487: 35.48		E9QAQ5_MOUSE (65-471): 6.92e-141: 413: 73.57
+	Mm
		926533 PP1G_MOUSE (33-341): 5.88e-171: 486: 35.96		CDK2_MOUSE (116-413): 1.84e-137: 401: 27.40