HitPredict

Interactor 1: GSH1 (P48506)
Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase)
Gene: GCLC

Interactor 2: GSH0 (P48507)
Glutamate--cysteine ligase regulatory subunit (GCS light chain) (Gamma-ECS regulatory subunit) (Gamma-glutamylcysteine synthetase regulatory subunit) (Glutamate--cysteine ligase modifier subunit)
Gene: GCLM

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 0.60 0.704

The method score is based on:

Property Details
Experiments 33961781, 28514442, 9675072, 9841880
Identification Methods affinity chromatography technology, biochemical, pull down, anti tag coimmunoprecipitation, chromatography technology
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0004357 - glutamate-cysteine ligase activity
GO:0005829 - cytosol
GO:0006534 - cysteine metabolic process
GO:0006536 - glutamate metabolic process
GO:0006750 - glutathione biosynthetic process
and 17 others

more...
Homologous interactions 5

Homologous interactions

Color coding for hit scores

1 637
Hs

1 274
+ Mm
+ Rn
+ Ce
+ Ce
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024