HitPredict

Interactor 1: CD151 (P48509)
CD151 antigen (GP27) (Membrane glycoprotein SFA-1) (Platelet-endothelial tetraspan antigen 3) (PETA-3) (Tetraspanin-24) (Tspan-24) (CD antigen CD151)
Gene: CD151

Interactor 2: CD81 (P60033)
CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)
Gene: CD81

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	30024968, 23091066
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Tetraspanin~Tetraspanin
Common GO terms	GO:0005178 - integrin binding GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0016020 - membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 253 Hs			1 236
+	Hs
		819445 CD151_HUMAN (1-253): 6.35e-74: 227: 100.00		TSN5_HUMAN (7-235): 3.13e-55: 179: 21.67
+	Hs
		111521 K4DIA7_HUMAN (1-230): 1.96e-64: 202: 100.00		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		602230 CD151_HUMAN (1-253): 6.35e-74: 227: 100.00		CD9_HUMAN (1-234): 3.88e-53: 172: 43.59
+	Hs
		819462 CD151_HUMAN (1-253): 6.35e-74: 227: 100.00		TSN14_HUMAN (11-230): 6.42e-52: 170: 21.65
+	Hs
		887767 TSN5_HUMAN (3-250): 3e-63: 200: 23.40		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		653088 CD151_HUMAN (1-253): 6.35e-74: 227: 100.00		CD82_HUMAN (4-234): 1.57e-49: 164: 23.11
+	Hs
		887904 TSN14_HUMAN (4-250): 2.18e-59: 190: 23.86		CD81_HUMAN (1-236): 6.2e-63: 197: 100.00
+	Hs
		237719 CD151_HUMAN (1-253): 6.35e-74: 227: 100.00		TSN2_HUMAN (3-234): 1.88e-44: 150: 39.22
+	Hs
		326042 CD151_HUMAN (1-253): 6.35e-74: 227: 100.00		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48
+	Hs
		279369 TSN5_HUMAN (3-250): 3e-63: 200: 23.40		TSN9_HUMAN (5-233): 7.12e-53: 172: 26.05
+	Hs
		602239 TSN5_HUMAN (3-250): 3e-63: 200: 23.40		CD9_HUMAN (1-234): 3.88e-53: 172: 43.59
+	Hs
		905534 TSN5_HUMAN (3-250): 3e-63: 200: 23.40		TSN14_HUMAN (11-230): 6.42e-52: 170: 21.65
+	Hs
		602271 TSN14_HUMAN (4-250): 2.18e-59: 190: 23.86		CD9_HUMAN (1-234): 3.88e-53: 172: 43.59
+	Hs
		326051 TSN5_HUMAN (3-250): 3e-63: 200: 23.40		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48
+	Hs
		819465 CD151_HUMAN (1-253): 6.35e-74: 227: 100.00		TSN18_HUMAN (5-231): 2.35e-33: 122: 27.67
+	Hs
		209300 TSN6_HUMAN (13-253): 1.12e-59: 190: 27.80		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48
+	Hs
		326141 TSN14_HUMAN (4-250): 2.18e-59: 190: 23.86		TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48
+	Hs
		819464 CD151_HUMAN (1-253): 6.35e-74: 227: 100.00		Q8WUV1_HUMAN (6-215): 1.89e-09: 58.2: 28.15