HitPredict

Interactor 1: RAC2 (P48554)
Ras-related protein Rac2
Gene: RAC2

Interactor 2: PAK (Q9VI13)
Serine/threonine-protein kinase Pak (EC 2.7.11.1)
Gene: PAK

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.831

Property	Details
Experiments	10847683, 14527437
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PBD~Ras, Pkinase~Ras
Common GO terms	GO:0005856 - cytoskeleton GO:0007391 - dorsal closure GO:0050770 - regulation of axonogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Dm			1 704
+	Dm
		776915 RAC1_DROME (1-192): 2.59e-81: 241: 93.23		PAK_DROME (1-704): 0: 584: 100.00
+	Hs
		925648 RAC1_HUMAN (1-192): 5.39e-84: 248: 89.58		PAK6_HUMAN (74-702): 2.11e-144: 439: 29.01
+	Hs
		330841 RHOQ_HUMAN (4-179): 1.12e-84: 250: 66.48		PAK4_HUMAN (75-698): 1.09e-140: 426: 31.98
+	Hs
		330967 RAC1_HUMAN (1-192): 5.39e-84: 248: 89.58		PAK4_HUMAN (75-698): 1.09e-140: 426: 31.98
+	Hs
		925692 RAC1_HUMAN (1-192): 5.39e-84: 248: 89.58		PAK5_HUMAN (75-698): 1.23e-131: 407: 29.19
+	Hs
		564425 RHOQ_HUMAN (4-179): 1.12e-84: 250: 66.48		AKT2_HUMAN (360-704): 3.07e-132: 400: 22.65
+	Dd
		332055 RACF1_DICDI (1-179): 1.03e-94: 275: 71.51		PAKB_DICDI (417-704): 7.11e-77: 265: 49.32
+	Dd
		710119 RACA_DICDI (1-186): 7.76e-81: 253: 62.90		PAKB_DICDI (417-704): 7.11e-77: 265: 49.32
+	Dd
		710116 RAC1A_DICDI (1-192): 6.64e-81: 240: 79.38		PAKB_DICDI (417-704): 7.11e-77: 265: 49.32
+	Ce
		975572 RAC1_CAEEL (1-192): 1.93e-82: 244: 79.69		PK1_CAEEL (2-228): 1.52e-44: 170: 31.08
+	Hs
		564505 RHOQ_HUMAN (4-179): 1.12e-84: 250: 66.48		PAK1_HUMAN (5-257): 1.14e-38: 152: 30.68
+	Mm
		292040 RAC1_MOUSE (1-192): 5.39e-84: 248: 89.58		PAK1_MOUSE (5-257): 1.19e-38: 152: 30.68
+	Hs
		925244 RAC1_HUMAN (1-192): 5.39e-84: 248: 89.58		PAK1_HUMAN (5-257): 1.14e-38: 152: 30.68
+	Mm
		103566 RAC1_MOUSE (1-192): 5.39e-84: 248: 89.58		G5E884_MOUSE (5-257): 2.26e-38: 151: 30.04
+	Hs
		564507 RHOQ_HUMAN (4-179): 1.12e-84: 250: 66.48		PAK2_HUMAN (5-237): 5.74e-36: 144: 31.65
+	Hs
		925245 RAC1_HUMAN (1-192): 5.39e-84: 248: 89.58		PAK2_HUMAN (5-237): 5.74e-36: 144: 31.65
+	Hs
		277602 RAC1_HUMAN (1-192): 5.39e-84: 248: 89.58		PAK3_HUMAN (5-238): 4.93e-34: 139: 28.57
+	Mm
		925809 RAC1_MOUSE (1-192): 5.39e-84: 248: 89.58		PAK2_MOUSE (5-237): 2.89e-34: 139: 30.38
+	Sp
		963937 CDC42_SCHPO (1-192): 5.56e-81: 240: 67.19		SHK2_SCHPO (81-307): 4.76e-17: 87.1: 16.39
+	Dm
		776912 RAC1_DROME (1-192): 2.59e-81: 241: 93.23		Q9VEV1_DROME (71-185): 1.45e-11: 69.7: 27.27