HitPredict

Interactor 1: GYP3 (P48566)
GTPase-activating protein GYP3 (Multicopy suppressor of bud emergence 3) (Protein MSB3)
Gene: MSB3

Interactor 2: YPT6 (Q99260)
GTP-binding protein YPT6
Gene: YPT6

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	10559187, 10937877
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	RabGAP-TBC~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 633 Sc			1 215
+	Sc
		731185 GYP3_YEAST (1-633): 6.71e-180: 526: 100.00		VPS21_YEAST (7-215): 9.74e-42: 142: 38.07
+	Sc
		1015456 MSB4_YEAST (88-561): 3.31e-108: 337: 48.55		YPT6_YEAST (1-215): 4.28e-83: 247: 100.00
+	Hs
		894747 TBC9B_HUMAN (35-556): 8.65e-96: 321: 19.41		RAB8A_HUMAN (11-215): 2.51e-89: 263: 39.02
+	Hs
		894727 TBC8B_HUMAN (34-583): 1e-90: 305: 19.12		RAB8A_HUMAN (11-215): 2.51e-89: 263: 39.02
+	Hs
		232698 TBCD4_HUMAN (23-601): 1.23e-87: 299: 14.95		RAB2B_HUMAN (7-214): 2.25e-80: 240: 32.41
+	Hs
		914176 TBCD1_HUMAN (23-596): 1.15e-83: 286: 14.31		RB11A_HUMAN (1-214): 2.15e-83: 248: 32.09
+	Hs
		914482 RBGP1_HUMAN (31-629): 2.28e-83: 285: 16.92		RB11A_HUMAN (1-214): 2.15e-83: 248: 32.09
+	Hs
		321281 TBCD8_HUMAN (35-555): 1.65e-81: 280: 20.76		RB11A_HUMAN (1-214): 2.15e-83: 248: 32.09
+	Hs
		592719 RBGP1_HUMAN (31-629): 2.28e-83: 285: 16.92		RAB6A_HUMAN (5-215): 3.69e-81: 242: 59.54
+	Hs
		234370 EVI5_HUMAN (145-552): 2.64e-81: 274: 19.57		RB11A_HUMAN (1-214): 2.15e-83: 248: 32.09
+	Os
		772871 Q5SMT0_ORYSJ (27-507): 1.72e-84: 280: 16.37		RIC2_ORYSJ (1-214): 3.56e-80: 240: 27.98
+	Hs
		914465 TBD2B_HUMAN (111-573): 5.72e-78: 268: 23.03		RB11A_HUMAN (1-214): 2.15e-83: 248: 32.09
+	Hs
		234378 EVI5_HUMAN (145-552): 2.64e-81: 274: 19.57		RB11B_HUMAN (1-214): 3.37e-80: 240: 30.42
+	Hs
		914275 EVI5L_HUMAN (116-581): 1.48e-77: 264: 17.34		RB11A_HUMAN (1-214): 2.15e-83: 248: 32.09
+	Sc
		860838 GYP2_YEAST (180-571): 1.74e-76: 264: 22.65		YPT6_YEAST (1-215): 4.28e-83: 247: 100.00
+	Dm
		185735 Q8IPP5_DROME (2-613): 2.51e-89: 305: 15.16		O18339_DROME (11-197): 3.78e-42: 143: 40.43
+	Hs
		844684 SGSM3_HUMAN (138-571): 2.46e-79: 268: 24.37		RAB5C_HUMAN (4-196): 2.82e-45: 151: 38.00
+	Hs
		592434 SGSM3_HUMAN (138-571): 2.46e-79: 268: 24.37		RAB5A_HUMAN (4-213): 3.49e-44: 148: 37.14
+	Hs
		592584 TBD2B_HUMAN (111-573): 5.72e-78: 268: 23.03		RAB5A_HUMAN (4-213): 3.49e-44: 148: 37.14
+	Hs
		895374 SGSM3_HUMAN (138-571): 2.46e-79: 268: 24.37		RAB5B_HUMAN (8-213): 6.68e-43: 145: 37.86