HitPredict

Interactor 1: IF4E (P48598)
Eukaryotic translation initiation factor 4E1 (eIF-4F 25 kDa subunit) (mRNA cap-binding protein)
Gene: eIF4E1

Interactor 2: 4EBP (Q9XZ56)
Eukaryotic translation initiation factor 4E-binding protein (4E-BP) (d4E-BP) (eIF4E-binding protein) (4E-binding protein Thor) (dThor)
Gene: Thor

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.982

Property	Details
Experiments	22068330, 27626673, 25179781, 22833128, 25294943, 23716590, 26294658, 27773676, 15804566, 14605208, 36638908, unassigned4
Identification Methods	affinity chromatography technology, two hybrid, far western blotting, pull down, experimental interaction detection, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	IF4E~eIF_4EBP
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031594 - neuromuscular junction
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 259 Dm			1 117
+	Hs
		416983 IF4E_HUMAN (67-259): 6.14e-102: 297: 50.26		4EBP2_HUMAN (1-117): 3.79e-53: 164: 38.33
+	Mm
		926368 IF4E_MOUSE (61-259): 3.4e-102: 298: 48.26		4EBP2_MOUSE (1-117): 9.83e-53: 163: 38.33
+	Dm
		1373363 Q9VRY0_DROME (75-259): 5.92e-97: 285: 71.89		4EBP_DROME (1-117): 2.3e-52: 162: 100.00
+	Hs
		237212 IF4E2_HUMAN (44-251): 1.37e-95: 282: 31.46		4EBP2_HUMAN (1-117): 3.79e-53: 164: 38.33
+	Dm
		1373550 Q9VSB6_DROME (63-259): 5.85e-95: 280: 60.91		4EBP_DROME (1-117): 2.3e-52: 162: 100.00
+	Dm
		1376673 Q9W5B3_DROME (80-259): 1.58e-92: 280: 67.78		4EBP_DROME (1-117): 2.3e-52: 162: 100.00
+	Dm
		1373609 Q9VSG1_DROME (63-259): 3.3e-92: 273: 53.30		4EBP_DROME (1-117): 2.3e-52: 162: 100.00
+	Hs
		416982 IF4E_HUMAN (67-259): 6.14e-102: 297: 50.26		4EBP1_HUMAN (1-117): 3.1e-36: 121: 36.13
+	Rn
		926380 IF4E_RAT (61-259): 3.4e-102: 298: 48.26		4EBP1_RAT (1-117): 9.19e-36: 120: 36.13
+	Mm
		926370 IF4E_MOUSE (61-259): 3.4e-102: 298: 48.26		4EBP1_MOUSE (1-117): 2.21e-34: 116: 36.13
+	Hs
		237211 IF4E2_HUMAN (44-251): 1.37e-95: 282: 31.46		4EBP1_HUMAN (1-117): 3.1e-36: 121: 36.13
+	Mm
		1141831 IF4E2_MOUSE (44-251): 7.33e-97: 285: 31.93		4EBP1_MOUSE (1-117): 2.21e-34: 116: 36.13
+	Hs
		64108 I4E1B_HUMAN (54-259): 2.5e-94: 278: 43.87		4EBP1_HUMAN (1-117): 3.1e-36: 121: 36.13
+	Hs
		236380 IF4E_HUMAN (67-259): 6.14e-102: 297: 50.26		4EBP3_HUMAN (29-117): 3.39e-27: 97.9: 42.70
+	Hs
		236378 IF4E2_HUMAN (44-251): 1.37e-95: 282: 31.46		4EBP3_HUMAN (29-117): 3.39e-27: 97.9: 42.70