HitPredict

Interactor 1: PRS4 (P48601)
26S proteasome regulatory subunit 4 (P26s4)
Gene: Rpt2

Interactor 2: PSDE (Q9V3H2)
26S proteasome non-ATPase regulatory subunit 14 (EC 3.4.19.-) (26S proteasome regulatory complex subunit p37B) (26S proteasome regulatory subunit rpn11) (Yippee-interacting protein 5)
Gene: Rpn11

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22036573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	JAB~Prot_ATP_ID_OB
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005838 - proteasome regulatory particle GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 439 Dm			1 308
+	At
		1339598 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSDE_ARATH (1-307): 8.62e-106: 312: 76.62
+	Hs
		130831 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PSDE_HUMAN (18-308): 2.22e-103: 306: 89.69
+	Dm
		186131 PRS8_DROME (60-438): 2.22e-125: 371: 45.71		PSDE_DROME (1-308): 1.38e-110: 324: 100.00
+	Sc
		797499 PRS10_YEAST (9-436): 8.69e-144: 419: 37.82		RPN11_YEAST (1-308): 2.9e-89: 270: 63.96
+	Sp
		736963 PRS4_SCHPO (24-436): 6.09e-126: 374: 75.42		RPN11_SCHPO (1-307): 1.77e-101: 301: 67.21
+	Hs
		130770 PRS7_HUMAN (8-439): 1.59e-123: 367: 37.16		PSDE_HUMAN (18-308): 2.22e-103: 306: 89.69
+	Hs
		130835 PRS10_HUMAN (49-433): 5.5e-124: 366: 40.26		PSDE_HUMAN (18-308): 2.22e-103: 306: 89.69
+	Hs
		130832 PRS8_HUMAN (43-438): 1.09e-122: 364: 44.28		PSDE_HUMAN (18-308): 2.22e-103: 306: 89.69
+	Sc
		771715 PRS4_YEAST (1-439): 7.64e-131: 386: 70.62		RPN11_YEAST (1-308): 2.9e-89: 270: 63.96
+	Dm
		640769 PRS4_DROME (1-439): 7.01e-141: 411: 100.00		PSMD7_DROME (25-306): 4.42e-60: 196: 14.83
+	Hs
		849176 PRS4_HUMAN (24-439): 8.92e-138: 404: 92.55		PSMD7_HUMAN (26-306): 2.48e-60: 197: 16.96
+	Hs
		730324 PRS7_HUMAN (8-439): 1.59e-123: 367: 37.16		CSN5_HUMAN (1-305): 2e-73: 230: 30.70
+	Hs
		913330 PRS10_HUMAN (49-433): 5.5e-124: 366: 40.26		CSN5_HUMAN (1-305): 2e-73: 230: 30.70
+	At
		1320084 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSD7B_ARATH (13-308): 5.03e-56: 185: 16.50
+	At
		188943 PRS4A_ARATH (1-439): 4.1e-137: 402: 77.43		PSD7A_ARATH (13-308): 8.5e-56: 184: 16.83
+	Dm
		186102 PRS8_DROME (60-438): 2.22e-125: 371: 45.71		PSMD7_DROME (25-306): 4.42e-60: 196: 14.83
+	Hs
		730219 PRS7_HUMAN (8-439): 1.59e-123: 367: 37.16		PSMD7_HUMAN (26-306): 2.48e-60: 197: 16.96
+	Hs
		849179 PRS10_HUMAN (49-433): 5.5e-124: 366: 40.26		PSMD7_HUMAN (26-306): 2.48e-60: 197: 16.96
+	Sc
		862687 PRS10_YEAST (9-436): 8.69e-144: 419: 37.82		RPN8_YEAST (27-147): 5.77e-12: 67.1: 27.56
+	Sc
		771745 PRS4_YEAST (1-439): 7.64e-131: 386: 70.62		RPN8_YEAST (27-147): 5.77e-12: 67.1: 27.56