HitPredict

Interactor 1: CDK5 (P48609)
Cyclin-dependent kinase 5 homolog (EC 2.7.11.22) (Cell division protein kinase 5)
Gene: CDK5

Interactor 2: Q9VXM1 (Q9VXM1)
LD22957p
Gene: CycD

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	14605208
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 294 Dm			1 481
+	Hs
		538471 CDK2_HUMAN (1-294): 6.23e-145: 410: 56.76		CCNB1_HUMAN (5-446): 1.15e-93: 292: 14.96
+	Hs
		538521 CDK3_HUMAN (1-293): 1.25e-142: 405: 56.80		CCNB1_HUMAN (5-446): 1.15e-93: 292: 14.96
+	Hs
		625350 CDK2_HUMAN (1-294): 6.23e-145: 410: 56.76		CCNA1_HUMAN (121-438): 1.05e-89: 283: 21.94
+	Hs
		303829 CDK2_HUMAN (1-294): 6.23e-145: 410: 56.76		CCNB2_HUMAN (5-434): 3.14e-89: 279: 19.12
+	Rn
		981205 Q6P751_RAT (1-294): 8.56e-145: 410: 56.42		CCND2_RAT (138-411): 2.1e-90: 278: 37.14
+	Hs
		590125 CDK2_HUMAN (1-294): 6.23e-145: 410: 56.76		CCNA2_HUMAN (23-434): 1.33e-85: 271: 19.58
+	Hs
		625155 CDK2_HUMAN (1-294): 6.23e-145: 410: 56.76		CCND2_HUMAN (138-408): 1.77e-87: 271: 37.36
+	Hs
		590162 CDK3_HUMAN (1-293): 1.25e-142: 405: 56.80		CCNA2_HUMAN (23-434): 1.33e-85: 271: 19.58
+	Hs
		624539 CDK2_HUMAN (1-294): 6.23e-145: 410: 56.76		CCNE1_HUMAN (53-449): 2.62e-83: 264: 15.49
+	Hs
		625156 CDK2_HUMAN (1-294): 6.23e-145: 410: 56.76		CCND3_HUMAN (144-407): 6.83e-84: 262: 38.49
+	Mm
		673122 CDK2_MOUSE (1-294): 8.89e-137: 392: 48.98		CCND2_MOUSE (138-407): 7.96e-91: 280: 37.27
+	Mm
		851183 CDK2_MOUSE (1-294): 8.89e-137: 392: 48.98		CCNA2_MOUSE (16-434): 1.09e-88: 279: 18.86
+	Hs
		624573 CDK3_HUMAN (1-293): 1.25e-142: 405: 56.80		CCNE1_HUMAN (53-449): 2.62e-83: 264: 15.49
+	Hs
		673140 CDK3_HUMAN (1-293): 1.25e-142: 405: 56.80		CCND3_HUMAN (144-407): 6.83e-84: 262: 38.49
+	Hs
		622358 CDK2_HUMAN (1-294): 6.23e-145: 410: 56.76		CCND1_HUMAN (138-407): 2.36e-76: 243: 36.63
+	Mm
		629211 CDK2_MOUSE (1-294): 8.89e-137: 392: 48.98		CCND1_MOUSE (138-407): 4.75e-83: 260: 36.26
+	Hs
		622427 CDK3_HUMAN (1-293): 1.25e-142: 405: 56.80		CCND1_HUMAN (138-407): 2.36e-76: 243: 36.63
+	Hs
		331629 CDK2_HUMAN (1-294): 6.23e-145: 410: 56.76		CCNE2_HUMAN (159-296): 2.6e-14: 76.6: 32.86
+	Hs
		625523 CDK2_HUMAN (1-294): 6.23e-145: 410: 56.76		Q8WUE3_HUMAN (159-296): 2.2e-14: 76.6: 32.86
+	Hs
		331637 CDK3_HUMAN (1-293): 1.25e-142: 405: 56.80		CCNE2_HUMAN (159-296): 2.6e-14: 76.6: 32.86