HitPredict

Interactor 1: PRC2A (P48634)
Protein PRRC2A (HLA-B-associated transcript 2) (Large proline-rich protein BAT2) (Proline-rich and coiled-coil-containing protein 2A) (Protein G2)
Gene: PRRC2A

Interactor 2: EZH1 (Q92800)
Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1)
Gene: EZH1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2157 Hs			1 747
+	Hs
		1080127 KMT2C_HUMAN (79-2077): 7.51e-50: 199: 10.05		EZH2_HUMAN (8-746): 0: 719: 62.78
+	Hs
		554310 MUC1_HUMAN (1123-2148): 1.84e-48: 193: 12.03		EZH2_HUMAN (8-746): 0: 719: 62.78
+	Hs
		807738 MAP1B_HUMAN (491-2148): 1.27e-36: 155: 8.83		EZH2_HUMAN (8-746): 0: 719: 62.78
+	Hs
		1080261 MINT_HUMAN (338-2157): 4.08e-29: 130: 10.26		EZH2_HUMAN (8-746): 0: 719: 62.78
+	Hs
		1080524 PRC2C_HUMAN (33-1884): 4.13e-12: 74.4: 11.13		EZH2_HUMAN (8-746): 0: 719: 62.78
+	Hs
		152654 KMT2D_HUMAN (411-984): 1.99e-09: 65.4: 19.37		EZH2_HUMAN (8-746): 0: 719: 62.78
+	Hs
		1127674 PRC2B_HUMAN (1-2145): 2.51e-121: 430: 25.60		EHMT2_HUMAN (419-733): 7.51e-74: 262: 23.10
+	Hs
		331745 MAP1B_HUMAN (491-2148): 1.27e-36: 155: 8.83		NSD2_HUMAN (471-730): 3.64e-61: 225: 24.09
+	Hs
		1056971 MDC1_HUMAN (907-2156): 1.96e-13: 78.7: 10.22		SETD2_HUMAN (181-733): 3.89e-76: 271: 14.90
+	Hs
		203821 CABIN_HUMAN (211-1108): 5.1e-10: 67.2: 11.31		SUV91_HUMAN (422-732): 2.51e-81: 267: 22.98
+	Hs
		331812 MDC1_HUMAN (907-2156): 1.96e-13: 78.7: 10.22		NSD2_HUMAN (471-730): 3.64e-61: 225: 24.09
+	Hs
		975285 KMT2C_HUMAN (79-2077): 7.51e-50: 199: 10.05		KMT2A_HUMAN (620-734): 4.36e-19: 95.1: 42.24
+	Hs
		1243853 KMT2C_HUMAN (79-2077): 7.51e-50: 199: 10.05		SET1B_HUMAN (620-733): 4.68e-19: 94.7: 41.38
+	Hs
		165699 KMT2C_HUMAN (79-2077): 7.51e-50: 199: 10.05		SET1A_HUMAN (612-733): 1.12e-18: 93.6: 39.52
+	Hs
		1056940 MDC1_HUMAN (907-2156): 1.96e-13: 78.7: 10.22		NSD1_HUMAN (472-730): 1.84e-55: 208: 23.55
+	Hs
		975294 TITIN_HUMAN (25-1264): 8.01e-19: 96.8: 11.60		KMT2A_HUMAN (620-734): 4.36e-19: 95.1: 42.24
+	Dm
		1215699 SPEN_DROME (27-2148): 1.16e-13: 79.7: 7.99		TRR_DROME (612-733): 4.02e-19: 95.1: 41.46
+	Hs
		152630 KMT2D_HUMAN (411-984): 1.99e-09: 65.4: 19.37		KMT2A_HUMAN (620-734): 4.36e-19: 95.1: 42.24
+	Hs
		152701 KMT2D_HUMAN (411-984): 1.99e-09: 65.4: 19.37		SET1B_HUMAN (620-733): 4.68e-19: 94.7: 41.38
+	Hs
		152553 KMT2D_HUMAN (411-984): 1.99e-09: 65.4: 19.37		SET1A_HUMAN (612-733): 1.12e-18: 93.6: 39.52