HitPredict

Interactor 1: NEST (P48681)
Nestin
Gene: NES

Interactor 2: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0051402 - neuron apoptotic process
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1621 Hs			1 826
+	Hs
		522551 MYH1_HUMAN (549-1583): 5.34e-33: 142: 10.34		HIF1A_HUMAN (1-826): 0: 741: 100.00
+	Hs
		1085714 MYH2_HUMAN (549-1583): 8.08e-33: 141: 9.95		HIF1A_HUMAN (1-826): 0: 741: 100.00
+	Hs
		1085739 MYH4_HUMAN (17-755): 1.14e-23: 111: 10.41		HIF1A_HUMAN (1-826): 0: 741: 100.00
+	Hs
		528376 MYH6_HUMAN (771-1488): 1.11e-23: 111: 7.35		HIF1A_HUMAN (1-826): 0: 741: 100.00
+	Hs
		502916 MYH3_HUMAN (771-1429): 7.51e-23: 109: 8.35		HIF1A_HUMAN (1-826): 0: 741: 100.00
+	Hs
		443370 VIME_HUMAN (8-343): 3.05e-118: 382: 28.32		AHR_HUMAN (7-745): 4.08e-113: 366: 15.97
+	Hs
		821810 NEST_HUMAN (1-1621): 1.09e-115: 404: 100.00		NPAS1_HUMAN (1-505): 3.83e-104: 335: 27.19
+	Hs
		649049 MYH9_HUMAN (729-1459): 1.22e-24: 115: 10.48		ARNT_HUMAN (7-652): 5.14e-103: 338: 17.06
+	Hs
		725093 MYH9_HUMAN (729-1459): 1.22e-24: 115: 10.48		NCOA3_HUMAN (1-746): 4.42e-98: 335: 15.31
+	Hs
		649050 MYH10_HUMAN (14-453): 1.66e-13: 78.4: 11.24		ARNT_HUMAN (7-652): 5.14e-103: 338: 17.06