HitPredict

Interactor 1: KC1D (P48730)
Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)
Gene: CSNK1D

Interactor 2: SMAD3 (P84022)
Mothers against decapentaplegic homolog 3 (MAD homolog 3) (Mad3) (Mothers against DPP homolog 3) (hMAD-3) (JV15-2) (SMAD family member 3) (SMAD 3) (Smad3) (hSMAD3)
Gene: SMAD3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.675

Property	Details
Experiments	18729074, 19139564, 32814053
Identification Methods	affinity chromatography technology, enzymatic study, tandem affinity purification, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0090263 - positive regulation of canonical Wnt signaling pathway
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 415 Hs			1 425
+	Hs
		822270 KC1D_HUMAN (1-415): 6.71e-142: 412: 100.00		SMAD2_HUMAN (1-425): 0: 589: 83.73
+	Hs
		943108 KC1G2_HUMAN (3-367): 5.17e-118: 351: 48.78		SMAD3_HUMAN (1-425): 0: 636: 100.00
+	Hs
		822256 KC1D_HUMAN (1-415): 6.71e-142: 412: 100.00		SMAD4_HUMAN (23-414): 1.55e-117: 355: 33.21