HitPredict

Interactor 1: PAXI (P49023)
Paxillin
Gene: PXN

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	10085298
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0005938 - cell cortex GO:0007165 - signal transduction and 1 others more... GO:0019903 - protein phosphatase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 591 Hs			1 217
+	Hs
		411641 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		782755 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		CSK_HUMAN (2-139): 3.92e-24: 100: 36.24
+	Hs
		557639 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		337395 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		789046 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Mm
		337635 PAXI_MOUSE (12-591): 2.7e-114: 354: 93.62		ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46
+	Hs
		412085 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433288 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		442793 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		433646 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		522857 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Mm
		403454 PAXI_MOUSE (12-591): 2.7e-114: 354: 93.62		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		300996 ABLM3_HUMAN (416-590): 1.41e-40: 158: 29.03		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924889 PDLI7_HUMAN (473-590): 2.88e-34: 137: 33.90		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		200163 TGFI1_HUMAN (1-532): 4.62e-63: 216: 24.91		CSK_HUMAN (2-139): 3.92e-24: 100: 36.24
+	Hs
		275170 ZN250_HUMAN (70-463): 7.31e-70: 237: 13.07		GRAP2_HUMAN (3-55): 1.58e-10: 61.3: 39.62
+	Hs
		442845 FHL5_HUMAN (381-590): 9.47e-63: 210: 29.44		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Hs
		111447 PDLI7_HUMAN (473-590): 2.88e-34: 137: 33.90		J3QRU1_HUMAN (52-215): 3.95e-13: 69.6: 14.29
+	Ce
		107567 G5EFG1_CAEEL (473-590): 4.79e-32: 133: 35.00		SRC2_CAEEL (118-215): 1.65e-14: 73.4: 22.00
+	Hs
		433484 PDLI7_HUMAN (473-590): 2.88e-34: 137: 33.90		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91