HitPredict

Interactor 1: PAXI (P49023)
Paxillin
Gene: PXN

Interactor 2: TRIP6 (Q15654)
Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1)
Gene: TRIP6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	14688263, 31980649, unassigned2173
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LIM~LIM
Common GO terms	GO:0001725 - stress fiber GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007165 - signal transduction and 1 others more... GO:0046872 - metal ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 591 Hs			1 476
+	Hs
		238966 LPXN_HUMAN (186-590): 2.88e-109: 334: 50.37		TRIP6_HUMAN (1-476): 4.58e-97: 302: 100.00
+	Hs
		823508 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		LIMD1_HUMAN (1-475): 1.08e-69: 236: 25.36
+	Hs
		238998 LPXN_HUMAN (186-590): 2.88e-109: 334: 50.37		LIMD1_HUMAN (1-475): 1.08e-69: 236: 25.36
+	Hs
		238982 LPXN_HUMAN (186-590): 2.88e-109: 334: 50.37		LPP_HUMAN (3-475): 1.2e-65: 224: 38.82
+	Hs
		1044595 FHL3_HUMAN (382-590): 1.13e-57: 196: 28.64		TRIP6_HUMAN (1-476): 4.58e-97: 302: 100.00
+	Hs
		823353 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		PAXI_HUMAN (258-395): 1.68e-28: 120: 25.90
+	Hs
		816247 LIMS1_HUMAN (346-529): 1.14e-43: 160: 32.97		TRIP6_HUMAN (1-476): 4.58e-97: 302: 100.00
+	Hs
		238992 LPXN_HUMAN (186-590): 2.88e-109: 334: 50.37		PDLI7_HUMAN (111-473): 4.43e-25: 109: 13.77
+	Hs
		823405 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		ZYX_HUMAN (91-467): 2.51e-15: 80.4: 18.02
+	Hs
		200167 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		TGFI1_HUMAN (268-337): 1.32e-11: 68.3: 27.14
+	Hs
		238967 LPXN_HUMAN (186-590): 2.88e-109: 334: 50.37		ZYX_HUMAN (91-467): 2.51e-15: 80.4: 18.02
+	Hs
		200190 TGFI1_HUMAN (1-532): 4.62e-63: 216: 24.91		TES_HUMAN (141-457): 1.24e-56: 195: 19.09
+	Hs
		1044729 FHL3_HUMAN (382-590): 1.13e-57: 196: 28.64		TES_HUMAN (141-457): 1.24e-56: 195: 19.09
+	Hs
		1136614 FHL5_HUMAN (381-590): 9.47e-63: 210: 29.44		PDLI7_HUMAN (111-473): 4.43e-25: 109: 13.77
+	Ce
		107596 PXL1_CAEEL (143-532): 1.7e-57: 200: 19.75		G5EFG1_CAEEL (10-390): 1.96e-26: 114: 16.50
+	Hs
		816231 LIMS1_HUMAN (346-529): 1.14e-43: 160: 32.97		PAXI_HUMAN (258-395): 1.68e-28: 120: 25.90
+	Hs
		238953 LIMS1_HUMAN (346-529): 1.14e-43: 160: 32.97		LPXN_HUMAN (337-474): 2.2e-28: 117: 22.60
+	Hs
		1044598 FHL3_HUMAN (382-590): 1.13e-57: 196: 28.64		ZYX_HUMAN (91-467): 2.51e-15: 80.4: 18.02
+	Ce
		107727 PXL1_CAEEL (143-532): 1.7e-57: 200: 19.75		G5EFL5_CAEEL (33-331): 1.68e-12: 71.9: 13.19