HitPredict

Interactor 1: PAXI (P49023)
Paxillin
Gene: PXN

Interactor 2: ZYX (Q15942)
Zyxin (Zyxin-2)
Gene: ZYX

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LIM~LIM
Common GO terms	GO:0001725 - stress fiber GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007179 - transforming growth factor beta receptor signaling pathway and 1 others more... GO:0046872 - metal ion binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 591 Hs			1 572
+	Hs
		823508 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		LIMD1_HUMAN (1-571): 7.16e-66: 228: 22.80
+	Hs
		823403 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		TRIP6_HUMAN (63-571): 6e-66: 224: 32.82
+	Hs
		238967 LPXN_HUMAN (186-590): 2.88e-109: 334: 50.37		ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00
+	Hs
		238998 LPXN_HUMAN (186-590): 2.88e-109: 334: 50.37		LIMD1_HUMAN (1-571): 7.16e-66: 228: 22.80
+	Hs
		238966 LPXN_HUMAN (186-590): 2.88e-109: 334: 50.37		TRIP6_HUMAN (63-571): 6e-66: 224: 32.82
+	Hs
		823353 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		PAXI_HUMAN (8-500): 3.72e-32: 132: 12.12
+	Hs
		1044598 FHL3_HUMAN (382-590): 1.13e-57: 196: 28.64		ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00
+	Hs
		816231 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		LIMS1_HUMAN (383-566): 1.09e-10: 65.1: 25.95
+	Hs
		200167 PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00		TGFI1_HUMAN (377-441): 9.8e-10: 63: 32.31
+	Hs
		1044595 FHL3_HUMAN (382-590): 1.13e-57: 196: 28.64		TRIP6_HUMAN (63-571): 6e-66: 224: 32.82
+	Hs
		238982 LPXN_HUMAN (186-590): 2.88e-109: 334: 50.37		LPP_HUMAN (4-495): 1.9e-13: 75.1: 13.92
+	Hs
		238953 LPXN_HUMAN (186-590): 2.88e-109: 334: 50.37		LIMS1_HUMAN (383-566): 1.09e-10: 65.1: 25.95
+	Hs
		816283 ZN160_HUMAN (124-529): 3.05e-95: 310: 11.17		LIMS1_HUMAN (383-566): 1.09e-10: 65.1: 25.95
+	Hs
		200190 TGFI1_HUMAN (1-532): 4.62e-63: 216: 24.91		TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28
+	Hs
		1044729 FHL3_HUMAN (382-590): 1.13e-57: 196: 28.64		TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28
+	Hs
		1044590 FHL3_HUMAN (382-590): 1.13e-57: 196: 28.64		FHL2_HUMAN (468-572): 2.68e-19: 90.1: 21.91
+	Hs
		977875 ZNF85_HUMAN (110-413): 5.24e-46: 173: 9.80		FHL2_HUMAN (468-572): 2.68e-19: 90.1: 21.91
+	Hs
		1044587 FHL3_HUMAN (382-590): 1.13e-57: 196: 28.64		FHL3_HUMAN (410-544): 1.63e-09: 61.2: 28.99